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Versatile Ti3C2Tx MXene for free-radical scavenging
Nano Research ( IF 9.5 ) Pub Date : 2021-09-09 , DOI: 10.1007/s12274-021-3751-y
Jiang Liu 1 , Wei Lu 1 , Xifeng Lu 2 , Lu Zhang 1 , Haifeng Dong 3 , Yingchun Li 1
Affiliation  

MXene, as an emerging two-dimensional (2D) material with ultrathin structure and fascinating physiochemical properties, has been widely explored in broad applications. Versatile functions of MXenes are continuously explored. This work presents distinctive feature of MXene-Ti3C2Tx nanosheets for free-radical (FRs) scavenging that never reported before. We demonstrated the mechanism and equation in regard to the reaction between Ti3C2Tx and H2O2, which was applied to design colorimetric H2O2 strip assay with good performance. The good FRs scavenging capability of Ti3C2Tx, including a series of reactive oxygen species (ROS) and reactive nitrogen species (RNS), was systemically confirmed. The antioxidation capability of Ti3C2Tx for protecting cells from oxidative damage was demonstrated using the oxidative damage model of alpha mouse liver 12 (AML-12) cells. This original work provides huge opportunities for MXenes in FR-related biomedical applications.



中文翻译:

用于自由基清除的多功能 Ti3C2Tx MXene

MXene作为一种新兴的二维(2D)材料,具有超薄结构和迷人的理化特性,在广泛的应用中得到了广泛的探索。不断探索 MXenes 的多功能功能。这项工作展示了用于清除自由基 (FRs)的 MXene-Ti 3 C 2 T x纳米片的独特特征,这是以前从未报道过的。我们论证了Ti 3 C 2 T x与H 2 O 2反应的机理和方程式,用于设计具有良好性能的比色H 2 O 2试纸法。Ti 3良好的 FRs 清除能力C 2 T x,包括一系列活性氧(ROS)和活性氮(RNS),得到系统证实。使用α小鼠肝12(AML-12)细胞的氧化损伤模型证明了Ti 3 C 2 T x保护细胞免受氧化损伤的抗氧化能力。这项原创工作为 MXenes 在 FR 相关的生物医学应用中提供了巨大的机会。

更新日期:2021-09-09
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