The sea buckthorn (Hippophae rhamnoides L.) berries are rich in various bioactive components and widely used as fruit and traditional medicine. In this study, a novel heteropolysaccharide fraction (SP0.1-1) was isolated from Sea buckthorn berries. SP0.1-1 is composed of mannose, glucose, galactose, and arabinose in the molar ratio of 1:2.3:1.9:11.2 with a core structure containing 1,4-linked-α-d-Glcp, 1,4,6-linked-α-d-Glcp and 1,4-linked-α-d-Manp residues as the backbone. And the side-chains comprised of 1,3,5-linked-α-l-Araf, 1,5-linked-α-l-Araf, terminal α-Araf and 1,4-linked-β-d-Galp. Furthermore, a diet supplemented with SP0.1-1 extended the mean lifespan, enhanced antioxidant enzyme (superoxide dismutase, SOD; glutathione peroxidase, GSH-Px; and catalase, CAT) activities, and decreased the malondialdehyde (MDA) level and hydrogen peroxide (H₂O₂)-induced mortality rate in fruit flies (Drosophila melanogaster). To summarize, the study's findings will provide evidence for the development of sea buckthorn polysaccharide products.

沙棘（Hippophae rhamnoides L.）浆果富含多种生物活性成分，广泛用作水果和传统药物。在这项研究中，从沙棘浆果中分离出一种新型杂多糖组分 (SP0.1-1)。SP0.1-1由甘露糖、葡萄糖、半乳糖和阿拉伯糖组成，摩尔比为1:2.3:1.9:11.2，核心结构含有1,4-连接-α- d - Glc p , 1,4, 6-连接-α- d -Glc p 和 1,4-连接-α- d -Man p残基作为骨架。侧链由 1,3,5-linked-α- l -Ara f , 1,5-linked-α- l -Ara f组成, 末端 α-Ara f和 1,4-linked-β- d -Gal p。此外，添加 SP0.1-1 的饮食延长了平均寿命，增强了抗氧化酶（超氧化物歧化酶，SOD；谷胱甘肽过氧化物酶，GSH-Px；和过氧化氢酶，CAT）的活性，并降低了丙二醛 (MDA) 水平和过氧化氢(H ₂ O _{2 ) 引起的果蝇 (} Drosophila melanogaster )死亡率。综上所述，该研究结果将为沙棘多糖产品的开发提供依据。