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Load-bearing hydrogels ionically reinforced through competitive ligand exchanges
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-31 , DOI: 10.1039/d1bm01170g Matteo Hirsch 1 , Mathias Steinacher 1 , Ran Zhao 1 , Esther Amstad 1
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-31 , DOI: 10.1039/d1bm01170g Matteo Hirsch 1 , Mathias Steinacher 1 , Ran Zhao 1 , Esther Amstad 1
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Fast advances in soft robotics and tissue engineering demand for new soft materials whose mechanical properties can be interchangeably and locally varied, thereby enabling, for example, the design of soft joints within an integral material. Inspired by nature, we introduce a competitive ligand-mediated approach to selectively and interchangeably reinforce metal-coordinated hydrogels. This is achieved by reinforcing carboxylate-containing hydrogels with Fe3+ ions. Key to achieving a homogeneous, predictable reinforcement of the hydrogels is the presence of weak complexation agents that delay the formation of metal-complexes within the hydrogels, thereby allowing a homogeneous distribution of the metal ions. The resulting metal-reinforced hydrogels show a compressive modulus of up to 2.5 MPa, while being able to withstand pressures as high as 0.6 MPa without appreciable damage. Competitive ligand exchanges offer an additional advantage: they enable non-linear compositional changes that, for example, allow the formation of joints within these hydrogels. These features open up new possibilities to extend the field of use of metal reinforced hydrogels to load-bearing applications that are omnipresent for example in soft robots and actuators.
中文翻译：
通过竞争性配体交换离子增强的承重水凝胶
软机器人和组织工程的快速发展需要新的软材料，其机械性能可以互换且局部变化，从而实现例如在整体材料中设计软关节。受大自然的启发，我们引入了一种竞争性配体介导的方法来选择性地和可互换地增强金属配位的水凝胶。这是通过用 Fe 3+增强含羧酸盐的水凝胶来实现的离子。实现水凝胶均匀、可预测增强的关键是弱络合剂的存在，其延迟了水凝胶内金属配合物的形成，从而允许金属离子的均匀分布。所得金属增强水凝胶的压缩模量高达 2.5 MPa，同时能够承受高达 0.6 MPa 的压力而不会造成明显损坏。竞争性配体交换提供了一个额外的优势：它们能够实现非线性组成变化，例如，允许在这些水凝胶内形成接头。这些特性开辟了新的可能性，将金属增强水凝胶的使用领域扩展到无所不在的承载应用，例如软机器人和执行器。
更新日期：2021-09-09
中文翻译：
通过竞争性配体交换离子增强的承重水凝胶
软机器人和组织工程的快速发展需要新的软材料，其机械性能可以互换且局部变化，从而实现例如在整体材料中设计软关节。受大自然的启发，我们引入了一种竞争性配体介导的方法来选择性地和可互换地增强金属配位的水凝胶。这是通过用 Fe 3+增强含羧酸盐的水凝胶来实现的离子。实现水凝胶均匀、可预测增强的关键是弱络合剂的存在，其延迟了水凝胶内金属配合物的形成，从而允许金属离子的均匀分布。所得金属增强水凝胶的压缩模量高达 2.5 MPa，同时能够承受高达 0.6 MPa 的压力而不会造成明显损坏。竞争性配体交换提供了一个额外的优势：它们能够实现非线性组成变化，例如，允许在这些水凝胶内形成接头。这些特性开辟了新的可能性，将金属增强水凝胶的使用领域扩展到无所不在的承载应用，例如软机器人和执行器。
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