Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation,European Journal of Organic Chemistry

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Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-09-08 , DOI: 10.1002/ejoc.202101059
Chunling Blue Lan ₁ , Karine Auclair ₂

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Ammonium chloride promotes the selective formation of monosubstituted ureas under microwave irradiation. Most nucleophiles, acid-labile functionalities, and protecting groups are well tolerated in this reaction. By avoiding transition metals and mineral acids, this methodology offers a more sustainable alternative for the synthesis of monosubstituted ureas and their analogs.