Brain areas affected by intranasal oxytocin show higher oxytocin receptor expression,European Journal of Neuroscience

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Brain areas affected by intranasal oxytocin show higher oxytocin receptor expression
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-09-08 , DOI: 10.1111/ejn.15447
Philippe C. Habets _{1,

2} , Christabel Mclain ₁ , Onno C. Meijer ₁

Affiliation

Neuroimaging studies suggest that intranasal oxytocin (IN-OXT) may modulate emotional and social processes by altering neural activity patterns. The extent of brain penetration after IN-OXT is unclear, and it is currently unknown whether IN-OXT can directly bind central oxytocin receptors (OXTRs). We investigated oxytocin pathway gene expression in regions affected by IN-OXT on task-based fMRI. We found that OXTR is more highly expressed in affected than unaffected subcortical regions; this effect did not vary by task type or sex. Cortical results revealed higher OXTR expression in regions affected by IN-OXT in emotional processing tasks and in male-only data. No significant differences were found in expression of the closely related vasopressin receptors. Our findings suggest that the mechanism by which IN-OXT may alter brain functionality involves direct activation of central OXTRs.

中文翻译：

受鼻内催产素影响的大脑区域显示出更高的催产素受体表达

神经影像学研究表明，鼻内催产素 (IN-OXT) 可以通过改变神经活动模式来调节情绪和社会过程。IN-OXT 后大脑渗透的程度尚不清楚，目前尚不清楚 IN-OXT 是否可以直接结合中枢催产素受体 (OXTRs)。我们在基于任务的 fMRI 上研究了受 IN-OXT 影响的区域的催产素途径基因表达。我们发现OXTR在受影响的皮层下区域比未受影响的皮层下区域表达更高；这种效果不会因任务类型或性别而异。皮质结果显示更高的OXTR在情绪处理任务和仅男性数据中受 IN-OXT 影响的区域的表达。密切相关的加压素受体的表达没有发现显着差异。我们的研究结果表明，IN-OXT 可能改变大脑功能的机制涉及中枢 OXTR 的直接激活。

更新日期：2021-10-20

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