Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice,Molecular Nutrition & Food Research

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Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-09-08 , DOI: 10.1002/mnfr.202100389
Isabelle E Logan ₁ , Natalia Shulzhenko ₂ , Thomas J Sharpton _{3,

4} , Gerd Bobe ₅ , Kitty Liu ₆ , Stephanie Nuss ₂ , Megan L Jones ₆ , Cristobal L Miranda ₇ , Stephany Vasquez-Perez ₂ , Jamie M Pennington ₈ , Scott W Leonard ₈ , Jaewoo Choi ₈ , Wenbin Wu ₈ , Manoj Gurung ₂ , Joyce P Kim ₆ , Malcolm B Lowry ₉ , Andrey Morgun ₁₀ , Claudia S Maier ₁₁ , Jan F Stevens ₇ , Adrian F Gombart ₁

Affiliation

Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
Carlson College of Veterinary Medicine, Corvallis, OR, 97331, USA.
Department of Microbiology, Oregon State University, Corvallis, OR, 97331, USA.
Department of Statistics, Oregon State University, Corvallis, OR, 97331, USA.
Department of Animal Sciences, Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
Department of Biochemistry and Biophysics, Corvallis, OR, 97331, USA.
Department of Pharmaceutical Sciences, Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
Department of Microbiology, Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, 97331, USA.
Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA.

The polyphenol xanthohumol (XN) improves dysfunctional glucose and lipid metabolism in diet-induced obesity animal models. Because XN changes intestinal microbiota composition, the study hypothesizes that XN requires the microbiota to mediate its benefits.

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