Objectives

It has been suggested that pregnant women were affected more severely during the late wave, as opposed to the early wave of the coronavirus disease 2019 (COVID-19) pandemic. The aim of our study was to compare the proportion of pregnant women among hospitalized women of childbearing age, their rate of intensive care (ICU) admission, need for mechanical ventilation and mortality during the waves.

Methods

The study is a retrospective analysis of claims data on women of childbearing age (16–49 years) admitted to 76 hospitals with a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection. The observation period was divided into first wave (7 March 2020 to 30 September 2020) and second wave (1 October to 17 April 2021). Co-morbidities derived from claims data were summarized in the Elixhauser Co-morbidity Index (ECI).

Results

A total of 1879 women were included, 532 of whom were pregnant. During the second wave, the proportion of pregnant women was higher (29.3% (484/1650) versus 21.0% (48/229), p < 0.01). They were older (mean ± SD 29.1 ± 5.9 years versus 27 ± 6.3 years, p 0.02 in the first wave) and had comparable co-morbidities (ECI mean ± SD 0.3 ± 3.5 versus –0.2 ± 2.0, p 0.30). Of the pregnant women, 6.2% (3/48) were admitted to ICU during the first wave versus 3.3% (16/484) during the second wave (OR 0.51, 95% CI 0.14–1.83, p 0.30), 2.1% (1/48) were ventilated versus 1.2% (6/484, OR 0.60, 95% CI 0.07–5.23, p 0.64). No deaths were observed among the hospitalized pregnant women in either wave.

Conclusions

Proportionally more pregnant women with COVID-19 were hospitalized in the second wave compared with the first wave but no more severe outcomes were registered.

中文翻译：

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2019 年第一波和连续波冠状病毒病期间孕妇的结果和比例：观察性队列研究

目标

有人认为，与 2019 年冠状病毒病 (COVID-19) 大流行的早期浪潮相比，孕妇在晚期浪潮中受到的影响更为严重。我们研究的目的是比较住院育龄妇女中孕妇的比例、重症监护 (ICU) 入住率、机械通气需求和波浪期间的死亡率。

方法

该研究是对 76 家医院确诊的严重急性呼吸系统综合症冠状病毒 2 感染的育龄妇女（16-49 岁）的索赔数据进行的回顾性分析。观察期分为第一波（2020年3月7日至2020年9月30日）和第二波（2021年10月1日至4月17日）。Elixhauser 共病指数 (ECI) 中总结了源自索赔数据的共病。

结果

共纳入 1879 名妇女，其中 532 名怀孕。在第二波中，孕妇的比例更高（29.3% (484/1650) 对 21.0% (48/229)，p < 0.01）。他们年龄较大（平均 ± SD 29.1 ± 5.9 岁与 27 ± 6.3 岁，第一波中 p = 0.02）并且具有可比的合并症（ECI 平均值 ± SD 0.3 ± 3.5 对 –0.2 ± 2.0，p = 0.30）。在孕妇中，第一波期间 6.2% (3/48) 与第二波期间 3.3% (16/484) 入住 ICU (OR 0.51, 95% CI 0.14–1.83, p 0.30), 2.1% ( 1/48) 与 1.2% (6/484, OR 0.60, 95% CI 0.07–5.23, p = 0.64) 进行通气。在任一波次中，住院孕妇中均未观察到死亡。

结论

与第一波相比，在第二波中住院的 COVID-19 孕妇比例更多，但没有记录到更严重的结果。