Catalyst-Free and Oxidant-Free Cascade Difluoroalkylation and Controllable C−F Bond Activation of Aryl Enol Acetates for the Synthesis of β-Fluoroenones and β-Enaminones,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Catalyst-Free and Oxidant-Free Cascade Difluoroalkylation and Controllable C−F Bond Activation of Aryl Enol Acetates for the Synthesis of β-Fluoroenones and β-Enaminones
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-09-08 , DOI: 10.1002/adsc.202100681
Wenshuang Li ₁ , Ruyan Liu ₁ , Ruonan Li ₁ , Shihaozhi Wang ₁ , Dianjun Li ₁ , Jinhui Yang ₁

Affiliation

Aryl enol acetates and DMF could promote radical difluoroalkylation of aryl enol acetates to generate α,α-difluoro-γ-ketoacetates without a catalyst, an oxidant, or a base. When using different bases, β-fluoroenones and β-enaminones were synthesized by controllable C−F bond activation. These transformations provide an alternative method for the cascade difluoroalkylation and C−F bonds activation of aryl enol acetates.

中文翻译：

芳基烯醇乙酸酯的无催化剂和无氧化剂级联二氟烷基化和可控 C-F 键活化，用于合成 β-氟代烯酮和 β-烯胺酮

芳基烯醇乙酸酯和 DMF 可以促进芳基烯醇乙酸酯的自由基二氟烷基化，在没有催化剂、氧化剂或碱的情况下生成 α,α-二氟-γ-酮乙酸酯。当使用不同的碱基时，β-氟烯酮和β-烯胺酮是通过可控的CF键活化合成的。这些转化为芳基烯醇乙酸酯的级联二氟烷基化和 C-F 键活化提供了一种替代方法。

更新日期：2021-09-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11