Renal microvascular disease associated with diabetes [Diabetic kidney disease - DKD] is the leading cause of chronic kidney disease. In DKD, glomerular basement membrane thickening, mesangial expansion, endothelial dysfunction, podocyte cell loss and renal tubule injury contribute to progressive glomerulosclerosis and tubulointerstitial fibrosis. Chronic inflammation is recognized as a major pathogenic mechanism for DKD, with resident and circulating immune cells interacting with local kidney cell populations to provoke an inflammatory response. The onset of inflammation is driven by the release of well described proinflammatory mediators, and this is typically followed by a resolution phase. Inflammation resolution is achieved through the bioactions of endogenous specialized pro-resolving lipid mediators (SPMs). As our understanding of SPMs advances ‘resolution pharmacology’ based approaches using these molecules are being explored in DKD.

与糖尿病相关的肾微血管疾病[糖尿病肾病-DKD]是慢性肾病的主要原因。在 DKD 中，肾小球基底膜增厚、系膜扩张、内皮功能障碍、足细胞丢失和肾小管损伤导致进行性肾小球硬化和肾小管间质纤维化。慢性炎症被认为是 DKD 的主要致病机制，常驻和循环免疫细胞与局部肾细胞群相互作用以引发炎症反应。炎症的发作是由充分描述的促炎介质的释放驱动的，这通常随后是消退阶段。炎症消退是通过内源性专门的促分解脂质介质 (SPM) 的生物作用来实现的。