Green Semisynthetic Cascade to Ligstroside, Ligstroside Aglycone, and Oleocanthal,ACS Sustainable Chemistry & Engineering

当前位置： X-MOL 学术 › ACS Sustain. Chem. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Green Semisynthetic Cascade to Ligstroside, Ligstroside Aglycone, and Oleocanthal
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2021-09-09 , DOI: 10.1021/acssuschemeng.1c04030
Stefano Mancuso ₁ , Paola Costanzo ₂ , Sonia Bonacci ₁ , Monica Nardi ₁ , Manuela Oliverio ₁ , Antonio Procopio ₁

Affiliation

Ligstroside, ligstroside aglycone, and oleocanthal are extra virgin olive oil (EVOO) bioactive phenols poorly represented in olive leaves. Semisynthetic pathways to achieve them, starting with largely available natural precursors, are proposed as alternative solution with respect to their low effective extraction or total synthesis. In the present work, we propose the first green chemocatalytic method to obtain, in the same semisynthetic cascade, ligstroside, ligstroside aglycone, and oleocanthal starting from oleuropein. The sustainability of the method was assessed by building the synthesis trees, while the green credentials of each step were analyzed through the CHEM21 toolkit, thus allowing consequent considerations on the large-scale feasibility.

中文翻译：

绿色半合成级联到女贞子苷、女贞子苷元和油橄榄素

Ligstroside、ligstroside 苷元和 oleocanthal 是特级初榨橄榄油 (EVOO) 生物活性酚，在橄榄叶中的含量很少。半合成途径来实现它们，从大量可用的天然前体开始，被提议作为替代解决方案，以解决它们的低效率提取或全合成。在目前的工作中，我们提出了第一种绿色化学催化方法，在相同的半合成级联中，从橄榄苦苷开始获得 ligstroside、ligstroside 苷元和油橄榄。通过构建合成树来评估该方法的可持续性，同时通过 CHEM21 工具包分析每个步骤的绿色证书，从而允许对大规模可行性进行后续考虑。

更新日期：2021-09-20

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11