Synthesis of Aporphine Analogues via Palladium-Catalyzed Intramolecular Aryl–Aryl Dehydrogenative Coupling,The Journal of Organic Chemistry

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Synthesis of Aporphine Analogues via Palladium-Catalyzed Intramolecular Aryl–Aryl Dehydrogenative Coupling
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-09-09 , DOI: 10.1021/acs.joc.1c01649
Chen Su ₁ , Wen-Hua Xu ₁ , Rui-Li Guo ₁ , Xing-Long Zhang ₁ , Xue-Qing Zhu ₁ , Ya-Ru Gao ₁ , Yong-Qiang Wang ₁

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Reported herein is an intramolecular dehydrogenative coupling of two inert aryl C–H bonds for the synthesis of aporphine analogues. The process represents a novel tool for the preparation of aporphines via palladiun-catalyzed C–H bond activation. The present reaction is compatible with various functional groups, and the coupling products have been further applied for the synthesis of natural products aporphine and zenkerine.

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