Attempt of developing bio-safety and functional layered double hydroxides (LDHs) modified plasma electrolytic oxidation (PEO) coatings, has become a hotspot in the protection of magnesium (Mg) based biomedical implants. In the present work, Mg-Fe LDH films with different Fe contents were fabricated on PEO coating via a novel two-step method: firstly, the FeOOH films were prepared by immersing PEO sample in Fe²⁺-containing solution, and then Mg-Fe LDH films were formed by transforming the FeOOH films via a hydrothermal treatment in water. The highly-oriented LDH nano-sheets could enhance the anti-corrosion performance of PEO coating, which was proved by the results of electrochemical test, hydrogen evolution and corroded morphology. PEO/Mg-Fe LDH coatings showed a low hemolysis rate (less 5%) than PEO coating. In addition, PEO/Mg-Fe LDH coatings were more favorable for cell adhesion and proliferation than PEO coating. Moreover, PEO/Mg-Fe LDH coatings showed good photothermal conversion property, which demonstrated the excellent rapid antibacterial effect under NIR light. In vitro culture of rat bone marrow stem cell (rBMSC) suggested that cells cultured in the extract of PEO/Mg-Fe LDH coatings had a better osteogenic activity. In vivo subcutaneous implantation test revealed that PEO/Mg-Fe LDH coatings exhibited good anti-corrosion and histocompatibility.

开发生物安全和功能性层状双氢氧化物 (LDH) 改性等离子体电解氧化 (PEO) 涂层的尝试已成为保护镁 (Mg) 基生物医学植入物的热点。在目前的工作中，通过一种新的两步法在 PEO 涂层上制备了具有不同 Fe 含量的 Mg-Fe LDH 薄膜：首先，通过将 PEO 样品浸入 Fe ²⁺中制备 FeOOH 薄膜。含溶液，然后通过在水中水热处理转化 FeOOH 薄膜形成 Mg-Fe LDH 薄膜。电化学测试、析氢和腐蚀形貌的结果证明了高度取向的LDH纳米片可以增强PEO涂层的防腐性能。PEO/Mg-Fe LDH 涂层显示出比 PEO 涂层低的溶血率（小于 5%）。此外，PEO/Mg-Fe LDH 涂层比 PEO 涂层更有利于细胞粘附和增殖。此外，PEO/Mg-Fe LDH涂层表现出良好的光热转换性能，在近红外光下表现出优异的快速抗菌效果。体外大鼠骨髓干细胞 (rBMSC) 的培养表明，在 PEO/Mg-Fe LDH 涂层提取物中培养的细胞具有更好的成骨活性。体内皮下植入试验表明，PEO/Mg-Fe LDH涂层表现出良好的抗腐蚀和组织相容性。