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Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2021-09-10 , DOI: 10.2147/ijn.s321882
Yanyan Zhou 1 , Zihe Hu 1 , Mingjie Ge 1 , Wenjing Jin 1 , Ruikang Tang 2 , Qi Li 1 , Weijian Xu 1 , Jue Shi 1 , Zhijian Xie 1
Affiliation  

Purpose: Osteoporosis, due to bone loss and structural deterioration, is a risk factor for dental implant failure, as it impedes initial stability and osseointegration. We aim to assess the effects of calcium phosphate polymer-induced liquid precursor (CaP-PILP) treatment, which significantly increases bone density and improves early implant osseointegration in ovariectomized rats.
Methods: In this study, CaP-PILP was synthesized and characterized through TEM, FTIR and XRD. A rat model of osteoporosis was generated by ovariectomy. CaP-PILP or hydroxyapatite (HAP, negative control) was injected into the tibia, and the resulting changes in bone quality were determined. Further, implants were installed in the treated tibias, and implantation characteristics were assessed after 4 weeks.
Results: The CaP-PILP group had superior bone repair. Importantly, CaP-PILP had excellent properties, similar to those of normal bone, in terms of implant osseointegration. In vivo experiment displayed that CaP-PILP group had better bone contact rate (65.97± 3.176) than HAP and OVX groups. Meanwhile, a mound of mature and continuous new bone formed. Moreover, the values of BIC and BA showed no significant difference between the CaP-PILP group and the sham group.
Conclusion: In summary, CaP-PILP is a promising material for application in poor-quality bones to improve implant success rates in patients with osteoporosis. This research provides new perspectives on the application of nano-apatite materials in bone repair.

Keywords: polymer-induced liquid precursor, calcium phosphates, nanocluster, osteoporosis, oral implant


中文翻译:


骨内注射磷酸钙聚合物诱导的液体前体可增加卵巢切除大鼠的骨密度并改善早期植入骨整合



目的:由于骨质流失和结构恶化而导致的骨质疏松症是牙种植体失败的危险因素,因为它阻碍了初始稳定性和骨整合。我们的目的是评估磷酸钙聚合物诱导的液体前体 (CaP-PILP) 治疗的效果,该治疗可显着增加卵巢切除大鼠的骨密度并改善早期种植体骨整合。

方法:本研究合成了CaP-PILP,并通过TEM、FTIR和XRD对其进行了表征。通过卵巢切除术建立骨质疏松症大鼠模型。将 CaP-PILP 或羟基磷灰石(HAP,阴性对照)注射到胫骨中,并测定由此产生的骨质量变化。此外,将植入物安装在治疗后的胫骨中,并在 4 周后评估植入特性。

结果: CaP-PILP 组具有优异的骨修复效果。重要的是,CaP-PILP 在种植体骨整合方面具有与正常骨相似的优异特性。体内实验表明,CaP-PILP组的骨接触率(65.97±3.176)优于HAP和OVX组。与此同时,一堆成熟的、连续的新骨形成。此外,CaP-PILP组和假手术组之间的BIC和BA值没有显着差异。

结论:综上所述,CaP-PILP 是一种很有前景的材料,可用于改善骨质疏松患者的骨质量,以提高骨质疏松症患者的种植成功率。该研究为纳米磷灰石材料在骨修复中的应用提供了新的视角。


关键词:聚合物诱导液体前体, 磷酸钙, 纳米团簇, 骨质疏松, 口腔种植体
更新日期:2021-09-09
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