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Association Between Blood Pressure and Branched-Chain/Aromatic Amino Acid Excretion Rate in 24-Hour Urine Samples from Elderly Hypertension Patients
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-09-10 , DOI: 10.2147/dmso.s324153 Faxuan Wang 1, 2 , Binxia Wang 3 , Xiyuan Chen 1, 2 , Wanlu Liu 1, 2 , Guoqi Wang 1, 2 , Xiaoxia Li 1, 2 , Xiuying Liu 1, 2 , Nan Li 1, 2 , Jiaxing Zhang 1, 2 , Ting Yin 1, 2 , Jinyun Jing 1, 2 , Xiaoyu Chang 4 , Yanan Jin 5 , Yuhong Zhang 1, 2 , Yi Zhao 1
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy ( IF 2.8 ) Pub Date : 2021-09-10 , DOI: 10.2147/dmso.s324153 Faxuan Wang 1, 2 , Binxia Wang 3 , Xiyuan Chen 1, 2 , Wanlu Liu 1, 2 , Guoqi Wang 1, 2 , Xiaoxia Li 1, 2 , Xiuying Liu 1, 2 , Nan Li 1, 2 , Jiaxing Zhang 1, 2 , Ting Yin 1, 2 , Jinyun Jing 1, 2 , Xiaoyu Chang 4 , Yanan Jin 5 , Yuhong Zhang 1, 2 , Yi Zhao 1
Affiliation
Background: Recently, the association between lifestyle-related diseases and free amino acids in the blood plasma—especially branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs)—has been highlighted. However, few studies have been carried out on 24-hour urine samples. Therefore, we aimed to explore the relationships between 24-hour urinary BCAAs and AAAs excretion rate and blood pressure (BP) in elderly patients with hypertension.
Methods and Results: Each of the 322 elderly patients with hypertension completed an in-person questionnaire interview, underwent a physical examination, and provided a 24-hour urine specimen. We measured their BCAAs and AAAs excretion rate, and used multiple linear regression analysis with variable selection to construct models describing the relationships between their BCAAs and AAAs excretion rate and BP. After adjusted for age, gender, height, and weight, valine was inversely associated with both systolic blood pressure (SBP) (β: − 0.232, 95% CI: − 0.16, − 0.006) and diastolic blood pressure (DBP) (β: − 0.144, 95% CI: − 0.089, − 0.005). These findings were invariant even following adjustment for urine volume and drugs history, and Ile was positively associated with DBP (β: 0.170, 95% CI: 0.001, 0.066).
Conclusion: The data revealed that the excretion rate of 24-hour urinary BCAAs was closely related to BP in elderly hypertension patients, and these findings will provide new insights into the association between BACC metabolism and BP.
中文翻译：
老年高血压患者 24 小时尿液样本中血压与支链/芳香族氨基酸排泄率之间的关联
背景：最近，生活方式相关疾病与血浆中游离氨基酸——尤其是支链氨基酸 (BCAAs) 和芳香族氨基酸 (AAAs) 之间的关联得到了强调。然而，很少有关于 24 小时尿液样本的研究。因此，我们旨在探讨老年高血压患者 24 小时尿 BCAAs 和 AAAs 排泄率与血压（BP）之间的关系。
方法和结果：322 名老年高血压患者均完成了面对面的问卷调查，接受了体格检查，并提供了 24 小时尿液样本。我们测量了他们的 BCAAs 和 AAAs 排泄率，并使用带有变量选择的多元线性回归分析来构建描述其 BCAAs 和 AAAs 排泄率与 BP 之间关系的模型。在调整年龄、性别、身高和体重后，缬氨酸与收缩压 (SBP) ( β : − 0.232, 95% CI: − 0.16, − 0.006) 和舒张压 (DBP) ( β : − 0.144, 95% CI: − 0.089, − 0.005)。即使在调整了尿量和药物史后，这些发现也没有变化，并且 Ile 与 DBP 呈正相关（β: 0.170, 95% CI: 0.001, 0.066)。
结论：数据显示老年高血压患者24小时尿BCAAs的排泄率与BP密切相关，这些发现将为BACC代谢与BP之间的关系提供新的见解。
更新日期：2021-09-09
Methods and Results: Each of the 322 elderly patients with hypertension completed an in-person questionnaire interview, underwent a physical examination, and provided a 24-hour urine specimen. We measured their BCAAs and AAAs excretion rate, and used multiple linear regression analysis with variable selection to construct models describing the relationships between their BCAAs and AAAs excretion rate and BP. After adjusted for age, gender, height, and weight, valine was inversely associated with both systolic blood pressure (SBP) (β: − 0.232, 95% CI: − 0.16, − 0.006) and diastolic blood pressure (DBP) (β: − 0.144, 95% CI: − 0.089, − 0.005). These findings were invariant even following adjustment for urine volume and drugs history, and Ile was positively associated with DBP (β: 0.170, 95% CI: 0.001, 0.066).
Conclusion: The data revealed that the excretion rate of 24-hour urinary BCAAs was closely related to BP in elderly hypertension patients, and these findings will provide new insights into the association between BACC metabolism and BP.
中文翻译：
老年高血压患者 24 小时尿液样本中血压与支链/芳香族氨基酸排泄率之间的关联
背景：最近，生活方式相关疾病与血浆中游离氨基酸——尤其是支链氨基酸 (BCAAs) 和芳香族氨基酸 (AAAs) 之间的关联得到了强调。然而，很少有关于 24 小时尿液样本的研究。因此，我们旨在探讨老年高血压患者 24 小时尿 BCAAs 和 AAAs 排泄率与血压（BP）之间的关系。
方法和结果：322 名老年高血压患者均完成了面对面的问卷调查，接受了体格检查，并提供了 24 小时尿液样本。我们测量了他们的 BCAAs 和 AAAs 排泄率，并使用带有变量选择的多元线性回归分析来构建描述其 BCAAs 和 AAAs 排泄率与 BP 之间关系的模型。在调整年龄、性别、身高和体重后，缬氨酸与收缩压 (SBP) ( β : − 0.232, 95% CI: − 0.16, − 0.006) 和舒张压 (DBP) ( β : − 0.144, 95% CI: − 0.089, − 0.005)。即使在调整了尿量和药物史后，这些发现也没有变化，并且 Ile 与 DBP 呈正相关（β: 0.170, 95% CI: 0.001, 0.066)。
结论：数据显示老年高血压患者24小时尿BCAAs的排泄率与BP密切相关，这些发现将为BACC代谢与BP之间的关系提供新的见解。
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