Thermogenesis-mediated energy expenditure is a promising strategy to combat obesity. Aframomum melegueta commonly known as grains of paradise (GP) is a popular spice with medicinal attributes in promoting health. We have demonstrated the thermogenic effects of a standardized A melegueta seed extract (AMSE) containing not <10% 6-paradol in high fat diet-fed (HFD) mice. The 6-week oral ingestion of 20 and 40 mg/kg AMSE significantly limited the weight gain, improved the brown adipose tissue (BAT) activity in HFD mice. Interestingly, AMSE markedly induced the beige adipocytes in epididymal white adipose tissue (eWAT). AMSE treatment led to the upregulation of marker proteins i.e., uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor-gamma-coactivator 1-alpha (PGC-1α), and peroxisome proliferator-activated receptor gamma (PPARγ) in eWAT and BAT. Our findings add to the current understanding of the thermogenic potentials of GP seed extract and report that the extract can stimulate the browning of WATs in addition to enhanced BAT activity. AMSE requires clinical validation to be explored as a dietary supplement/functional ingredient with thermogenic effect in food and beverages.

产热介导的能量消耗是对抗肥胖的一种很有前景的策略。Aframomum melegueta通常被称为天堂谷物 (GP)，是一种流行的香料，具有促进健康的药用特性。我们已经证明了标准化A melegueta的产热效应种子提取物 (AMSE) 在高脂肪饮食喂养 (HFD) 小鼠中含有不 <10% 6-paradol。6 周口服摄入 20 和 40 mg/kg AMSE 显着限制了体重增加，改善了 HFD 小鼠的棕色脂肪组织 (BAT) 活性。有趣的是，AMSE 显着诱导附睾白色脂肪组织 (eWAT) 中的米色脂肪细胞。AMSE 治疗导致标记蛋白上调，即 eWAT 和 BAT 中的解偶联蛋白 1 (UCP1)、过氧化物酶体增殖物激活受体-γ-共激活物 1-α (PGC-1α) 和过氧化物酶体增殖物激活受体 γ (PPARγ) . 我们的发现增加了目前对 GP 种子提取物产热潜力的理解，并报告说，除了增强 BAT 活性外，该提取物还可以刺激 WAT 的褐变。