Abstract

Two new polyisoprenylated benzophenones, planchoniones A (1) and B (2), together with two known benzophenones (3, 4) and six known xanthones (5-10), were isolated from an ethyl acetate extract of the pericarp of Garcinia planchonii Pierre. Their structures were established using spectroscopic methods, mainly 1D and 2D NMR. The four benzophenones were evaluated for their cytotoxicity against MCF-7 human breast cancer cells, and showed almost no activity. Meanwhile, compounds 5-10 were investigated for their inhibitory effects towards α-glucosidase, and γ-mangostin (5) exhibited the most remarkable effect with IC₅₀ value of 15.3 ± 0.9 µM (compared with acarbose, IC₅₀ = 224.9 ± 3.6 µM).

摘要

从Garcinia planchonii Pierre的果皮乙酸乙酯提取物中分离出两种新的聚异戊二烯化二苯甲酮，planchoniones A ( 1 ) 和 B ( 2 )，以及两种已知的二苯甲酮 ( 3, 4 ) 和六种已知的氧杂蒽酮 ( 5-10 ) . 它们的结构是使用光谱方法建立的，主要是一维和二维核磁共振。评估了四种二苯甲酮对 MCF-7 人乳腺癌细胞的细胞毒性，结果几乎没有活性。同时，研究了化合物5 - 10对 α-葡萄糖苷酶的抑制作用，其中 γ-mangostin (5) 的 IC _{50效果最为显着}值为 15.3 ± 0.9 µM（与阿卡波糖相比，IC ₅₀ = 224.9 ± 3.6 µM）。