Abstract

Two new sclerotioramines (1 and 2) and a new natural product of sclerotioramine analog (3), together with seven known compounds have been isolated from the mangrove endophytic fungus Penicillium sclerotiorin SCNU-F0040. Their structures were identified based on the 1 D, 2 D NMR and HRESIM spectra. The absolute configurations of new compounds were deduced by specific rotation data and electronic circular dichroism spectra. All the isolated new compounds were tested on anti-diabetes activity by using a-glucosidase inhibition assay and anti-inflammatory activity by using cyclooxygenase inhibition assay, respectively. Compounds 1 and 2 have a-glucosidase inhibition activity with IC₅₀ values of 102.3 and 217.5 μM. Compound 2 shows a moderate cyclooxygenase-2 inhibitory activity with an IC₅₀ value of 47.8 μM.

摘要

已从红树林内生真菌Penicillium sclerotiorin SCNU-F0040中分离出两种新的核盘胺（1和2）和一种新的核盘胺类似物天然产物（3 ）以及七种已知化合物。它们的结构是根据一维、二维核磁共振和 HRESIM 光谱鉴定的。新化合物的绝对构型是通过比旋光数据和电子圆二色光谱推导出来的。所有分离的新化合物分别通过α-葡萄糖苷酶抑制试验和环氧合酶抑制试验测试了抗糖尿病活性和抗炎活性。化合物1和2具有α-葡萄糖苷酶抑制活性与IC_{102.3 和 217.5 μM 的50 个}值。化合物2显示出中度环氧合酶 2 抑制活性，IC ₅₀值为 47.8 μM。