Abstract

Phytochemical investigation of the whole plants of Lycopodiella cernua resulted in the isolation and identification of three new compounds (1–3), namely lycocernuaside E (1), lycernuic ketone F (2), and lycernuic B (3) and 12 known ones (4–15). Their chemical structures were established based on 1 D/2D NMR spectroscopic and HR-ESI-MS data analyses. Compounds 5, 12, and 13 displayed NO inhibitory effects in LPS-stimulated BV2 cells, with IC₅₀ values of 21.2 ± 1.1, 28.5 ± 1.4, and 21.9 ± 1.1 µM, respectively. In addition, cytotoxic activity of the isolated compounds against MCF7 (breast carcinoma), HepG2 (hepatocarcinoma), and SK-Mel2 (melanoma) cancer cell lines were also reported.

摘要

Lycopodiella cernua全株植物化学研究分离鉴定出三种新化合物（1-3），即lycocernuaside E（1）、lycernuic ketone F（2）、lycernuic B（3）和12个已知化合物（4 - 15）。它们的化学结构是基于一维/二维核磁共振光谱和 HR-ESI-MS 数据分析建立的。化合物5、12和13在 LPS 刺激的 BV2 细胞中显示出 NO 抑制作用，IC ₅₀值分别为 21.2 ± 1.1、28.5 ± 1.4 和 21.9 ± 1.1 µM。此外，还报道了分离的化合物对 MCF7（乳腺癌）、HepG2（肝癌）和 SK-Mel2（黑色素瘤）癌细胞系的细胞毒活性。