Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) are part of the extended RFamide peptide family characterized by their common arginine (R) and amidated phenylalanine (F)-motif at the carboxyl terminus. Both peptides signal through their respective high affinity G-protein coupled receptors, NPFFR2 and NPFFR1, but also show binding affinity for the other receptor due to their sequence similarity. NPFF and NPVF are highly conserved throughout evolution and can be found across the whole animal kingdom. Both have been implicated in a variety of biological mechanisms, including nociception, locomotion, reproduction, and response to pain and stress. However, more recently a new major functional role in the control of energy homeostasis has been discovered. In this article we will summarise the current knowledge on the distribution of NPFF, NPVF, and their receptors in central and peripheral tissues, as well as how this relates to the regulation of food intake and energy balance, which will help to better understand their role in these processes and thus might help finding treatments for impaired energy homeostasis disorders, such as obesity or anorexia.

神经肽 FF (NPFF) 和神经肽 VF (NPVF) 是扩展的 RFamide 肽家族的一部分，其特征在于它们在羧基末端具有共同的精氨酸 (R) 和酰胺化苯丙氨酸 (F) 基序。两种肽都通过它们各自的高亲和力 G 蛋白偶联受体 NPFFR2 和 NPFFR1 发出信号，但由于它们的序列相似性，它们也显示出对其他受体的结合亲和力。NPFF 和 NPVF 在整个进化过程中高度保守，可以在整个动物王国中找到。两者都与多种生物学机制有关，包括伤害感受、运动、繁殖以及对疼痛和压力的反应。然而，最近发现了控制能量稳态的新的主要功能作用。在这篇文章中我们将总结目前关于NPFF、NPVF、