In a study by Law and colleagues recently published in Neuroimage, the authors reported that wearing a surgical mask during an fMRI scan leads to a statistically significant subject-specific change (30%) in the baseline BOLD level in gray matter, although the response to a sensory-motor task was unaffected. An average increase in end-tidal CO₂ of 7.4% was found when wearing a mask, despite little support in the literature for major effects of mask wearing on blood gas levels. We comment on these findings, point out a several relevant limitations of the study design and provide alternative interpretations of these data.

中文翻译：

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研究设计对戴口罩对 fMRI BOLD 对比度和全身生理学影响的影响——对 Law 等人的评论。(2021)

在 Law 及其同事最近发表在 Neuroimage 上的一项研究中，作者报告说，在 fMRI 扫描期间戴上外科口罩会导致灰质基线 BOLD 水平发生统计学上显着的受试者特异性变化（30%），尽管对感觉运动任务不受影响。尽管文献很少支持戴口罩对血气水平的主要影响，但戴口罩时发现呼气末 CO ₂平均增加7.4%。我们对这些发现发表评论，指出研究设计的几个相关限制，并提供对这些数据的替代解释。