Several clinical studies have reported that xanthine oxidoreductase inhibitors have antihypertensive and renal protective effects but their mechanisms have not been fully determined. This study aims to clarify these mechanisms by examining the effects of febuxostat, which is a novel selective xanthine oxidoreductase inhibitor, in Dahl salt-sensitive rats.

中文翻译：

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非布索坦可改善 Dahl 盐敏感大鼠的高盐摄入引起的高血压和肾损伤。

几项临床研究报道，黄嘌呤氧化还原酶抑制剂具有抗高血压和肾脏保护作用，但其作用机制尚未完全确定。本研究旨在通过检查非布索坦（一种新型选择性黄嘌呤氧化还原酶抑制剂）对达尔盐敏感性大鼠的作用来阐明这些机制。