Copper Metallogel as Potential Drug Carrier for Anti-Inflammatory Drugs,ChemistrySelect

当前位置： X-MOL 学术 › ChemistrySelect › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper Metallogel as Potential Drug Carrier for Anti-Inflammatory Drugs
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-09-09 , DOI: 10.1002/slct.202102490
Priyanka Choudhary ₁ , Ruchi Gaur ₂ , Darsi Rambabu ₃ , Abhimanew Dhir ₂ , Ankush Gupta ₄ , Pooja ₅

Affiliation

Copper based Metal-Organic Gels (MOGs) were evaluated for their efficiency as drug carrier for four anti-inflammatory drugs viz. 5-Fluorouracil (5FU), Phenidone (PN), Ibuprofen (IBP) and Cisplatin (CP). Copper(II)-benzene tricarboxylic acid (CuBTC) was used as a precursor for the loading and releasing of these drugs. The distinctive porous nature of the gel provided the high loading efficiency for these anti-inflammatory drugs. Among all the drugs evaluated, CuBTC@5FU exhibited maximum drug loading (88.1 %) and releasing (95 %) efficiency at physiological pH 5.2, which was attributed to the strong hydrogen bonding interactions between CuBTC and fluoride of 5FU.

中文翻译：

铜金属凝胶作为抗炎药物的潜在药物载体

评估了铜基金属有机凝胶 (MOG) 作为四种抗炎药物的药物载体的效率，即。5-氟尿嘧啶 (5FU)、菲尼酮 (PN)、布洛芬 (IBP) 和顺铂 (CP)。铜（II）-苯三羧酸（CuBTC）被用作这些药物的负载和释放的前体。凝胶独特的多孔性质为这些抗炎药物提供了高负载效率。在所有评估的药物中，CuBTC@5FU 在生理 pH 值为 5.2 时表现出最大的载药量（88.1%）和释放效率（95%），这归因于 CuBTC 与 5FU 氟化物之间的强氢键相互作用。

更新日期：2021-09-09

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11