TET-Like Oxidation in 5-Methylcytosine and Derivatives: A Computational and Experimental Study,ChemBioChem

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TET-Like Oxidation in 5-Methylcytosine and Derivatives: A Computational and Experimental Study
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-09 , DOI: 10.1002/cbic.202100420
Niko S W Jonasson ₁ , Rachel Janßen ₁ , Annika Menke ₁ , Fabian L Zott ₁ , Hendrik Zipse ₁ , Lena J Daumann ₁

Affiliation

The reactivity of a biomimetic iron(IV)-oxo complex 1 towards a number of methylated cytosine and uracil substrates was investigated. The reaction rates are in very good agreement with the calculated BDEs. C-Methylated compounds such as 5mC, T and 5miC possess a different reactivity than the solely N-methylated compounds 1mC and 1mU.

中文翻译：

5-甲基胞嘧啶及其衍生物中的 TET 样氧化：计算和实验研究

研究了仿生铁 (IV)-氧复合物1对多种甲基化胞嘧啶和尿嘧啶底物的反应性。反应速率与计算的 BDE 非常吻合。 C-甲基化化合物如 5mC、T 和 5m i C 具有与单独的N-甲基化化合物 1mC 和 1mU 不同的反应性。

更新日期：2021-09-09

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