The relationship between childhood asthma and gastro-oesophageal reflux (GOR) is contentious. Recent studies in adult asthmatics suggest that GOR is associated with worse control and differences in sputum proteomics related to epithelial integrity, systemic inflammation and host defence. We assessed 127 children with severe asthma undergoing bronchoscopy and pH study. There were no differences in asthma control or measures of airway inflammation or remodelling when those with acid GOR were compared with those without. These results suggest that acid GOR is not an important comorbidity in paediatric severe asthma.

中文翻译：

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严重哮喘患者伴有酸性胃食管反流的气道炎症

儿童哮喘与胃食管反流（GOR）之间的关系存在争议。最近对成人哮喘患者的研究表明，GOR 与较差的控制以及与上皮完整性、全身炎症和宿主防御相关的痰蛋白质组学差异有关。我们评估了 127 名接受支气管镜检查和 pH 值研究的重度哮喘儿童。与没有酸性 GOR 的患者相比，在哮喘控制或气道炎症或重塑方面没有差异。这些结果表明酸性 GOR 不是儿童重症哮喘的重要合并症。