Messenger RNA (mRNA) coronavirus disease of 2019 (COVID-19) vaccine are known to cause minor side effects at the injection site and mild global systemic symptoms in first 24–48 h. Recently published case series have reported a possible association between acute myocarditis and COVID-19 vaccination, predominantly in young males. We report a case series of 5 young male patients with cardiovascular magnetic resonance (CMR)-confirmed acute myocarditis within 72 h after receiving a dose of an mRNA-based COVID-19 vaccine. Our case series suggests that myocarditis in this setting is characterized by myocardial edema and late gadolinium enhancement in the lateral wall of the left ventricular (LV) myocardium, reduced global LV longitudinal strain, and preserved LV ejection fraction. All patients in our series remained clinically stable during a relatively short inpatient hospital stay. In conjunction with other recently published case series and national vaccine safety surveillance data, this case series suggests a possible association between acute myocarditis and COVID-19 vaccination in young males and highlights a potential pattern in accompanying CMR abnormalities.

中文翻译：

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接种 mRNA COVID-19 疫苗后患有急性心肌炎的年轻成年患者的心血管磁共振结果：病例系列


已知 2019 年信使 RNA (mRNA) 冠状病毒病 (COVID-19) 疫苗会在注射部位引起轻微副作用，并在最初 24-48 小时内引起轻微的全身全身症状。最近发表的病例系列报道了急性心肌炎与 COVID-19 疫苗接种之间可能存在关联，主要发生在年轻男性中。我们报告了 5 名年轻男性患者在接受一剂基于 mRNA 的 COVID-19 疫苗后 72 小时内经心血管磁共振 (CMR) 确诊为急性心肌炎的病例系列。我们的病例系列表明，这种情况下的心肌炎的特点是心肌水肿和左心室 (LV) 心肌侧壁的晚期钆增强、左心室整体纵向应变减少和左心室射血分数保留。我们系列中的所有患者在相对较短的住院期间均保持临床稳定。结合其他最近发布的病例系列和国家疫苗安全监测数据，该病例系列表明年轻男性的急性心肌炎与 COVID-19 疫苗接种之间可能存在关联，并强调了伴随 CMR 异常的潜在模式。