Human papillomavirus (HPV) associated cancers are increasingly reported globally, including in sub-Saharan Africa (SSA). However, with the exception of cervical HPV infection, data from SSA on the epidemiology of oral and genital HPV infections are limited. This study assessed the prevalence and concordance of oro-genital and anal HPV genotype specific infections among women in the general population. We conducted a cross-sectional study in sexually active women aged 18–45 years in Ibadan, Nigeria. After a face-to-face interview and clinical examination, oral, cervical, vulvar, and anal samples were collected from participants and tested by the Anyplex II 28 HPV assay. Descriptive and multivariable analyses were used to report prevalence and risk factors associated with HPV infections. The prevalence of any vulva, cervical, anal, and oral HPV infections was 68.0% (210/309), 59.7% (182/305), 56.8% (172/303), and 16.1% (14/286), respectively. There was an inverse relationship between age-group and HPV prevalence of HPV in all anatomic sites except for the oral HPV infections. HPV 35 was the most prevalent high-risk HPV genotype in the vulva, cervix and oral cavity. Associated risk factors for HPV infection in each of the anatomic sites were reported. Overall, 10.0% (31/310) women had concordance of any HPV type in the four anatomic sites. There was a high prevalence of oro-genital and anal HPV infections among sexually active Nigerian women, with concordance of HPV types in the cervix, vulva, anus and oral cavity. We advocate large longitudinal studies that will involve sampling of multiple anatomic sites and inclusion of other women in the community for better understanding of HPV epidemiology in this region.

中文翻译：

---

性活跃的尼日利亚女性口生殖器和肛门人乳头瘤病毒感染的患病率和基因型特异性一致性

人乳头瘤病毒 (HPV) 相关癌症在全球范围内的报道越来越多，包括在撒哈拉以南非洲 (SSA)。然而，除了宫颈 HPV 感染之外，SSA 关于口腔和生殖器 HPV 感染流行病学的数据有限。本研究评估了一般人群中女性口生殖器和肛门 HPV 基因型特异性感染的流行率和一致性。我们对尼日利亚伊巴丹的 18-45 岁性活跃女性进行了一项横断面研究。在面对面访谈和临床检查后，从参与者那里收集口腔、宫颈、外阴和肛门样本，并通过 Anyplex II 28 HPV 检测进行测试。描述性和多变量分析用于报告与 HPV 感染相关的患病率和危险因素。任何外阴、宫颈、肛门、口腔HPV感染率分别为68.0%（210/309）、59.7%（182/305）、56.8%（172/303）和16.1%（14/286）。除口腔 HPV 感染外，年龄组别与 HPV 在所有解剖部位的 HPV 感染率呈负相关。HPV 35 是外阴、宫颈和口腔中最普遍的高危 HPV 基因型。报告了每个解剖部位 HPV 感染的相关危险因素。总体而言，10.0% (31/310) 的女性在四个解剖部位具有任何 HPV 类型的一致性。在性活跃的尼日利亚女性中，口生殖器和肛门 HPV 感染的流行率很高，宫颈、外阴、肛门和口腔中的 HPV 类型一致。