The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities. We performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created. We included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively. TB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed. CRD42019147488

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结核病相关残疾：系统评价和荟萃分析

可持续发展目标旨在到 2030 年改善所有人的健康。其中纳入了有关结核病 (TB) 的雄心勃勃的目标，结核病可能是导致残疾的一个重要原因，但尚未量化。因此，我们的目的是量化结核病相关残疾的患病率和类型。我们对结核病相关残疾进行了系统评价。使用逆方差异质性模型计算残疾的汇总患病率。创建了按国家收入水平划分的常见残疾类型比例的地图。我们总共纳入了在 49 个国家进行的 131 项研究（217,475 名患者）。最常见的残疾类型是精神健康障碍（23.1%）、呼吸障碍（20.7%）、肌肉骨骼障碍（17.1%）、听力障碍（14.5%）、视力障碍（9.8%）、肾功能障碍（5.7%）、和神经功能障碍（1.6%）。低收入国家中呼吸障碍（61.2%）和精神健康障碍（42.0%）的患病率最高，而中低收入国家中神经系统障碍的患病率最高（25.6%）。耐药结核病分别与呼吸系统（58.7%）、神经系统（37.2%）、听力障碍（25.0%）和精神健康障碍（26.0%）相关。与结核病相关的残疾经常被报道。迫切需要针对结核病相关残疾的更统一的报告工具，并进一步研究以更好地量化和减轻残疾。CRD42019147488