Long noncoding RNAs (lncRNAs) are critical players during cancer progression. Nevertheless, the effect of most lncRNAs in lung cancer (LC) remains unclear. We aimed to explore the role of LINC01342 in LC development through the microRNA-508-5p (miR-508-5p)/cysteine-rich secretory protein 3 (CRISP3) axis. LINC01342, miR-508-5p, and CRISP3 expression in clinical samples and cell lines were determined, and their correlations in LC were analyzed. The prognostic role of LINC01342 in LC patients was evaluated. LC cells were screened and, respectively, transfected to alter the expression of LINC01342, miR-508-5p, and CRISP3. Then, proliferation, migration, invasion, and apoptosis of transfected LC cells were determined, and the in vivo tumor growth was observed as well. Binding relationships between LINC01342 and miR-508-5p, and between miR-508-5p and CRISP3 were identified. LINC01342 and CRISP3 were upregulated and miR-508-5p was downregulated in LC tissues and cells. High LINC01342 expression indicated a poor prognosis of LC patients. The LINC01342/CRISP3 silencing or miR-508-5p elevation inhibited proliferation, migration, and invasion of LC cells and promoted LC cell apoptosis, and also suppressed the in vivo tumor growth. LINC01342 bound to miR-508-5p and miR-508-5p targeted CRISP3. LINC01342 plays a prognostic role in LC and LINC01342 silencing upregulates miR-508-5p to inhibit the progression of LC by reducing CRISP3.

长链非编码 RNA (lncRNA) 是癌症进展过程中的关键参与者。然而，大多数lncRNAs在肺癌（LC）中的作用仍不清楚。我们旨在通过 microRNA-508-5p (miR-508-5p)/富含半胱氨酸的分泌蛋白 3 (CRISP3) 轴探索 LINC01342 在 LC 发育中的作用。测定临床样品和细胞系中的 LINC01342、miR-508-5p 和 CRISP3 表达，并分析它们在 LC 中的相关性。评估了 LINC01342 在 LC 患者中的预后作用。筛选和分别转染 LC 细胞以改变 LINC01342、miR-508-5p 和 CRISP3 的表达。然后测定转染LC细胞的增殖、迁移、侵袭和凋亡情况，并观察体内肿瘤生长情况。LINC01342与miR-508-5p的结合关系，并且在 miR-508-5p 和 CRISP3 之间进行了鉴定。在 LC 组织和细胞中，LINC01342 和 CRISP3 被上调，而 miR-508-5p 被下调。高 LINC01342 表达表明 LC 患者预后不良。LINC01342/CRISP3沉默或miR-508-5p升高抑制LC细胞的增殖、迁移和侵袭，促进LC细胞凋亡，同时抑制体内肿瘤生长。LINC01342 与 miR-508-5p 结合，miR-508-5p 靶向 CRISP3。LINC01342 在 LC 中发挥预后作用，LINC01342 沉默通过减少 CRISP3 上调 miR-508-5p 以抑制 LC 的进展。LINC01342/CRISP3沉默或miR-508-5p升高抑制LC细胞的增殖、迁移和侵袭，促进LC细胞凋亡，同时抑制体内肿瘤生长。LINC01342 与 miR-508-5p 结合，miR-508-5p 靶向 CRISP3。LINC01342 在 LC 中发挥预后作用，LINC01342 沉默通过减少 CRISP3 上调 miR-508-5p 以抑制 LC 的进展。LINC01342/CRISP3沉默或miR-508-5p升高抑制LC细胞的增殖、迁移和侵袭，促进LC细胞凋亡，同时抑制体内肿瘤生长。LINC01342 与 miR-508-5p 结合，miR-508-5p 靶向 CRISP3。LINC01342 在 LC 中发挥预后作用，LINC01342 沉默通过减少 CRISP3 上调 miR-508-5p 以抑制 LC 的进展。