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In vivo wound healing efficiency of curcumin-incorporated pectin-chitosan biodegradable films
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2021-09-09 , DOI: 10.1039/d1nj03477d V. Muthulakshmi 1 , G. R. Rajarajeswari 1
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2021-09-09 , DOI: 10.1039/d1nj03477d V. Muthulakshmi 1 , G. R. Rajarajeswari 1
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Drug-loaded biopolymeric films have been garnering the attention of wound care markets worldwide due to their enormous capacity to be customized and biodegradable features. In this context, this work presents the fabrication of pectin (PT)-chitosan (CS) blended films loaded with the proven transdermal drug, namely, curcumin. The thermal stability, mechanical strength, and water vapor barrier ability of the PT film were enhanced with the addition of CS. The addition of curcumin (CC) further improved these characteristics in the films. Among the prepared films, PC4/CC1.5 exhibited optimal thermal and mechanical properties as well as antibacterial activity against both the Gram-positive and negative bacteria; hence, it was chosen to be conducive for wound dressing applications. All the films were biodegraded in 30 days. In vivo studies with albino rats demonstrated the superior wound dressing ability of the PC4/CC1.5 film in completely healing the wound in 12 days. Histopathology studies indicated well-organized collagen deposition and formation of the thin epidermal layer at the wound site healed by the PC4/CC1.5 film and hence, endorsed the effectiveness of the curcumin-loaded film as a wound dressing material with the potential to be explored for further clinical studies.
中文翻译：
掺入姜黄素的果胶-壳聚糖可生物降解薄膜的体内伤口愈合效率
载药生物聚合物薄膜因其巨大的定制能力和可生物降解特性而引起了全球伤口护理市场的关注。在这种情况下，这项工作介绍了装载经证实的透皮药物，即姜黄素的果胶 (PT)-壳聚糖 (CS) 混合薄膜的制造。CS的加入提高了PT薄膜的热稳定性、机械强度和水蒸气阻隔能力。添加姜黄素 (CC) 进一步改善了薄膜的这些特性。在制备的薄膜中，PC4/CC1.5 表现出最佳的热性能和机械性能以及对革兰氏阳性和阴性细菌的抗菌活性；因此，它被选为有利于伤口敷料应用。所有薄膜在 30 天内生物降解。对白化病大鼠的体内研究表明 PC4/CC1.5 薄膜在 12 天内完全愈合伤口方面具有卓越的伤口敷料能力。组织病理学研究表明，在 PC4/CC1.5 薄膜愈合的伤口部位，组织良好的胶原蛋白沉积和薄表皮层的形成，因此，证实了加载姜黄素的薄膜作为伤口敷料材料的有效性，有可能探索进一步的临床研究。
更新日期：2021-09-09
中文翻译：
掺入姜黄素的果胶-壳聚糖可生物降解薄膜的体内伤口愈合效率
载药生物聚合物薄膜因其巨大的定制能力和可生物降解特性而引起了全球伤口护理市场的关注。在这种情况下，这项工作介绍了装载经证实的透皮药物，即姜黄素的果胶 (PT)-壳聚糖 (CS) 混合薄膜的制造。CS的加入提高了PT薄膜的热稳定性、机械强度和水蒸气阻隔能力。添加姜黄素 (CC) 进一步改善了薄膜的这些特性。在制备的薄膜中，PC4/CC1.5 表现出最佳的热性能和机械性能以及对革兰氏阳性和阴性细菌的抗菌活性；因此，它被选为有利于伤口敷料应用。所有薄膜在 30 天内生物降解。对白化病大鼠的体内研究表明 PC4/CC1.5 薄膜在 12 天内完全愈合伤口方面具有卓越的伤口敷料能力。组织病理学研究表明，在 PC4/CC1.5 薄膜愈合的伤口部位，组织良好的胶原蛋白沉积和薄表皮层的形成，因此，证实了加载姜黄素的薄膜作为伤口敷料材料的有效性，有可能探索进一步的临床研究。
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