Tailoring the mechanoresponsive release from silica nanocapsules,Nanoscale

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Tailoring the mechanoresponsive release from silica nanocapsules
Nanoscale ( IF 5.8 ) Pub Date : 2021-09-06 , DOI: 10.1039/d1nr04697g
Fabian Uebel ₁ , Héloïse Thérien-Aubin _{1,

2} , Katharina Landfester ₁

Affiliation

Triggering the release of encapsulated cargos using mechanical stress acting on a nanocarrier is a strategy with potential applications from drug delivery to self-healing coatings. The mechanically triggered release of encapsulated molecules can be controlled by tuning the mechanical properties of the nanocapsules, which are strongly linked to the nanocapsule architecture. Here, silica nanocarriers were designed to tune precisely the release initiated by mechanical stress. We synthesized silica nanocapsules (SiNCs) with a finely tunable diameter and shell thickness and performed AFM nanoindentation experiments to determine the breaking force of single SiNCs. We demonstrated that it is possible to trigger the release of encapsulated payload by the application of an external mechanical force on the SiNCs. Furthermore, we successfully controlled the breaking force and the amount of released payload by tailoring the architecture of the nanocarriers, illustrating how such mechanoresponsive SiNCs could be used as responsive nanocarriers for the delivery of molecular cargos.

中文翻译：

调整二氧化硅纳米胶囊的机械响应释放

使用作用于纳米载体的机械应力触发封装货物的释放是一种具有从药物递送到自修复涂层的潜在应用的策略。可以通过调节纳米胶囊的机械性能来控制包封分子的机械触发释放，这与纳米胶囊结构密切相关。在这里，二氧化硅纳米载体旨在精确调节机械应力引发的释放。我们合成了直径和壳厚度可微调的二氧化硅纳米胶囊 (SiNCs)，并进行了 AFM 纳米压痕实验以确定单个 SiNCs 的断裂力。我们证明了通过在 SiNC 上施加外部机械力来触发封装有效载荷的释放是可能的。此外，

更新日期：2021-09-09

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