Effects of QingYi decoction on inflammatory markers in patients with acute pancreatitis: A meta-analysis,Phytomedicine

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Effects of QingYi decoction on inflammatory markers in patients with acute pancreatitis: A meta-analysis
Phytomedicine ( IF 6.7 ) Pub Date : 2021-09-08 , DOI: 10.1016/j.phymed.2021.153738
Guanyu Wang ₁ , Dong Shang ₁ , Guixin Zhang ₁ , Shenglin Zhang ₁ , Nan Jiang ₂ , Huanhuan Liu ₃ , Hailong Chen ₁

Affiliation

Introduction

: It is widely accepted that inflammatory responses play a key role in acute pancreatitis (AP). We conducted a systematic review and meta-analysis to determine the effect of QingYi decoction on inflammatory markers.

Methods

: The PubMed, EMBASE, Cochrane, CNKI, CBM, and WANFGANG databases were searched for randomized controlled trials published before December 2019. Thirty-eight eligible studies were included in the meta-analysis. The quality of the included studies was assessed using the Cochrane Collaboration risk of bias tool. The standardized mean differences (SMDs) with corresponding 95% CIs were examined for inflammatory markers. The chi-square test and I² statistic were used to assess heterogeneity. We assessed publication bias by Begg's test, Egger's test, and the trim and fill method. In addition, a meta-regression, sensitivity analysis, subgroup analysis, and cumulative meta-analysis were performed to assess the effects of confounding factors. The quality of evidence was evaluated by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.

Results

: The pooled effect estimate indicated that QingYi decoction treatment significantly reduced the levels of pro-inflammatory IL-6 (SMD=-3.33; 95% CI, -4.17, -2.50; P<0.001; I²:97.9%), IL-8 (SMD=-1.55; 95%CI, -2.03, -1.07; P<0.001; I²: 96.1%), TNF-α (SMD=-1.04; 95%CI, -1.37, -0.72; P<0.001; I²: 93.9%), IL-1 (SMD=-2.05; 95%CI, -3.21, -0.90; p<0.001; I²: 93.4%), and IL-1β (SMD= -1.31; 95% CI, -2.42, -0.21; p<0.001; I²: 89.8%) and elevated the levels of anti-inflammatory IL-10 (SMD= 0.99; 95% CI, 0.60, 1.38; P<0.001; I²: 91.1%) among patients with AP. Conclusion: The current review and meta-analysis suggest that the therapeutic effect of QingYi decoction may be related to its anti-inflammatory properties. Due to the high heterogeneity across the included studies, additional large-scale and rigorously designed studies are needed to confirm the conclusions of this study.

中文翻译：

清衣汤对急性胰腺炎患者炎症标志物影响的Meta分析

介绍

:人们普遍认为炎症反应在急性胰腺炎 (AP) 中起关键作用。我们进行了系统评价和荟萃分析，以确定清衣汤对炎症标志物的影响。

方法

：检索了 PubMed、EMBASE、Cochrane、CNKI、CBM 和 WANFGANG 数据库中 2019 年 12 月之前发表的随机对照试验。荟萃分析纳入了 38 项符合条件的研究。使用 Cochrane Collaboration 偏倚风险工具评估纳入研究的质量。检查了具有相应 95% CI 的标准化平均差 (SMD) 的炎症标志物。卡方检验和 I ²统计量用于评估异质性。我们通过 Begg 检验、Egger 检验和修剪和填充方法评估发表偏倚。此外，还进行了荟萃回归、敏感性分析、亚组分析和累积荟萃分析，以评估混杂因素的影响。证据质量通过推荐分级评估、开发和评估 (GRADE) 系统进行评估。

结果

：汇总效应估计表明，清衣汤治疗显着降低促炎性 IL-6 水平（SMD=-3.33；95% CI，-4.17，-2.50；P<0.001；I ²：97.9%）、IL- 8 (SMD=-1.55; 95%CI, -2.03, -1.07; P<0.001; I ² : 96.1%), TNF-α (SMD=-1.04; 95%CI, -1.37, -0.72; P<0.001 ; I ² : 93.9%)、IL-1 (SMD=-2.05; 95%CI, -3.21, -0.90; p<0.001; I ² : 93.4%) 和 IL-1β (SMD= -1.31; 95% CI, -2.42, -0.21; p<0.001; I ² : 89.8%) 并升高抗炎 IL-10 的水平 (SMD= 0.99; 95% CI, 0.60, 1.38; P<0.001; I ² : 91.1 %) 在 AP 患者中。结论：目前的综述和荟萃分析表明，清衣汤的治疗作用可能与其抗炎特性有关。由于纳入研究的高度异质性，需要更多的大规模和严格设计的研究来证实本研究的结论。

更新日期：2021-09-09

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