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Modern Analytical Techniques for Drug Delivery Systems Characterization
Current Analytical Chemistry ( IF 1.7 ) Pub Date : 2021-09-30 , DOI: 10.2174/1573411016999200612100927
Iulia Rus 1 , Mihaela Tertis 1 , Cecilia Cristea 1 , Robert Sandulescu 1
Affiliation  

Recently, different strategies such as personalized therapy, dose adjustment, therapy monitoring and targeted drug delivery (disease-specific localization), were adopted for improving efficacy ratio of medicines that are currently in use. From a therapeutical point of view, to reach the optimal concentrations in the target organ or tissue, it is necessary to increase the administered dose, which is accompanied by an increase in the frequency and intensity of the side effects, many of them undesirable and distressing for the patient. Therefore, designing targeted delivery systems for a specific organ or tissue is the ideal solution, ensuring the necessary concentrations at the site of action and avoiding or at least significantly reducing the side effects. An overview of the modern analytical techniques currently used for the drug delivery systems characterization was intended in this review with a focus on those commonly used.



中文翻译:

药物输送系统表征的现代分析技术

最近,通过个性化治疗、剂量调整、治疗监测和靶向给药(疾病特异性定位)等不同策略来提高目前使用的药物的疗效比。从治疗的角度来看,为了在靶器官或组织中达到最佳浓度,必须增加给药剂量,这伴随着副作用的频率和强度的增加,其中许多是不希望的和令人痛苦的为患者。因此,为特定器官或组织设计靶向递送系统是理想的解决方案,可确保作用部位达到必要的浓度,并避免或至少显着减少副作用。

更新日期:2021-09-09
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