Background: Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early and later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medicinal, clinical and pharmaceutical research. Voltammetry is one of the most commonly used electroanalytical methods. This review aims to gather and discuss studies of voltammetric methods used in determination of dopamine agonists.

Methods: This review includes the use of various voltammetric methods for determination studies of dopamine agonists from pharmaceutical dosage forms and biological samples. These studies were examined in terms of used voltammetric method or methods, working electrode, buffer, pH and validation parameters.

Results: Cabergoline, pramipexole, and ropinirole have more studies, while bromocriptine and apomorphine have fewer studies in the literature. Differential pulse voltammetry and square wave voltammetry methods were the most applied methods for the determination of dopamine agonist drugs from pharmaceuticals and biological samples. But, stripping, cyclic and linear sweep voltammetry methods are less applied methods. In these studies, a lot of modified electrodes were developed and used to analyse dopamine agonists.

Conclusion: The voltammetric methods provide the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations without the necessity for the sample pre-treatment or time consuming extraction steps. Also, the modified electrodes and validated voltammetric methods provide good stability, repeatability, reproducibility and high recovery for the analysis of the analyte.

背景：多巴胺激动剂是治疗帕金森病早期和晚期患者的有用药物。帕金森病是一种进行性神经退行性疾病，主要影响大脑中产生多巴胺的神经细胞。它们与调节身体运动和运动功能的神经细胞中的多巴胺受体结合。电分析方法用于医学、临床和药物研究。伏安法是最常用的电分析方法之一。本综述旨在收集和讨论用于测定多巴胺激动剂的伏安法的研究。

方法：本综述包括使用各种伏安法测定药物剂型和生物样品中多巴胺激动剂的研究。根据使用的伏安法、工作电极、缓冲液、pH 值和验证参数对这些研究进行了检查。

结果：卡麦角林、普拉克索和罗匹尼罗的研究较多，而溴隐亭和阿扑吗啡的文献研究较少。差分脉冲伏安法和方波伏安法是测定药物和生物样品中多巴胺激动剂药物应用最广泛的方法。但是，剥离法、循环伏安法和线性扫描伏安法应用较少。在这些研究中，开发了许多改进的电极并用于分析多巴胺激动剂。

结论：伏安法可以测定临床样品中极低浓度的治疗剂和/或其代谢物，而无需样品预处理或耗时的提取步骤。此外，改进的电极和经过验证的伏安法为分析物的分析提供了良好的稳定性、重复性、再现性和高回收率。