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Changes of Gastric Juice Microenvironment in Patients with Fundic Gland Polyp and Hyperplastic Polyp
Pathobiology ( IF 3.5 ) Pub Date : 2021-09-09 , DOI: 10.1159/000516855 He Gao 1 , Lili Chang 2 , Limin Wang 3 , Xiaona Zhou 2 , Ning Wang 2
Pathobiology ( IF 3.5 ) Pub Date : 2021-09-09 , DOI: 10.1159/000516855 He Gao 1 , Lili Chang 2 , Limin Wang 3 , Xiaona Zhou 2 , Ning Wang 2
Affiliation
Introduction: The aim of this study was to study the relationship between the formation of gastric fundic gland polyp and gastric hyperplastic polyp (HP) and the changes of gastric juice microenvironment. Methods: The proton-pump inhibitor (PPI) applications to patients were recorded. Gastric juices and biopsy polyps were collected for pathological examination, H. pylori tests, biomarkers, and MUC1, MUC2, MUC5AC expression measurement. Results: Among 34,892 patients, the detection rate of gastric fundic gland polyps was significantly higher than that of gastric HPs (p #x3c; 0.01). The incidence rate of gastric fundic gland polyp and gastric HP in PPI users (n = 3,886) was higher than that of non-PPI users (p #x3c; 0.01). The occurrence of polyp was positively related to the duration of PPI application and the H. pylori-positive rate. The bile reflux rate between fundic gland polys group (17.61%) and HPs (28.67%) was significantly different (p #x3c; 0.01). The levels of gastric juice Gastrin-17, epidermal growth factor (EGF) and MUC2 from patients with gastric fundic gland polyps and gastric HPs were higher than those in the control group (p #x3c; 0.01). However, patients with gastric fundic gland polyps and HPs had significantly lower gastric juice PGE2 and MUC5AC (p #x3c; 0.01). Conclusion: PPI application, H. pylori infection, and bile reflux are the potential risk factors for formation of fundic gland polyps and HPs. The potential mechanism of polyps’ formation can be related to the levels of Gastrin-17, EGF, MUC2, PGE2, and MUC5AC in gastric juice.
Pathobiology
中文翻译：
胃底腺息肉和增生性息肉患者胃液微环境的变化
引言：本研究旨在研究胃底腺息肉和胃增生性息肉（HP）的形成与胃液微环境变化的关系。方法：记录质子泵抑制剂（PPI）对患者的应用情况。收集胃液和活检息肉用于病理学检查、幽门螺杆菌检测、生物标志物和MUC1、 MUC2、 MUC5AC表达测量。结果： 34892例患者中，胃底腺息肉检出率明显高于胃HPs（ p#x3c; 0.01)。PPI使用者胃底腺息肉和胃HP的发生率（n =3886）高于非PPI使用者（p #x3c；0.01）。息肉的发生与PPI应用时间和H. pylori阳性率呈正相关。胃底腺polys组（17.61%）和HPs（28.67%）的胆汁反流率有显着差异（p #x3c；0.01）。胃底腺息肉和胃HPs患者的胃液Gastron-17、表皮生长因子（EGF）和MUC 2水平高于对照组（p#x3c; 0.01)。然而，胃底腺息肉和 HPs 患者的胃液 PGE 2和 MUC5AC 显着降低 ( p #x3c; 0.01)。结论： PPI应用、H. pylori感染、胆汁反流是胃底腺息肉和HPs形成的潜在危险因素。息肉形成的潜在机制可能与胃液中Gastrin-17、EGF、MUC 2、PGE 2和MUC5AC的水平有关。
病理学
更新日期：2021-09-09
Pathobiology
中文翻译：
胃底腺息肉和增生性息肉患者胃液微环境的变化
引言：本研究旨在研究胃底腺息肉和胃增生性息肉（HP）的形成与胃液微环境变化的关系。方法：记录质子泵抑制剂（PPI）对患者的应用情况。收集胃液和活检息肉用于病理学检查、幽门螺杆菌检测、生物标志物和MUC1、 MUC2、 MUC5AC表达测量。结果： 34892例患者中，胃底腺息肉检出率明显高于胃HPs（ p#x3c; 0.01)。PPI使用者胃底腺息肉和胃HP的发生率（n =3886）高于非PPI使用者（p #x3c；0.01）。息肉的发生与PPI应用时间和H. pylori阳性率呈正相关。胃底腺polys组（17.61%）和HPs（28.67%）的胆汁反流率有显着差异（p #x3c；0.01）。胃底腺息肉和胃HPs患者的胃液Gastron-17、表皮生长因子（EGF）和MUC 2水平高于对照组（p#x3c; 0.01)。然而，胃底腺息肉和 HPs 患者的胃液 PGE 2和 MUC5AC 显着降低 ( p #x3c; 0.01)。结论： PPI应用、H. pylori感染、胆汁反流是胃底腺息肉和HPs形成的潜在危险因素。息肉形成的潜在机制可能与胃液中Gastrin-17、EGF、MUC 2、PGE 2和MUC5AC的水平有关。
病理学
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