There is a growing body of scientific research showing the link between depression and dementia in Alzheimer’s disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron.

中文翻译：

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慢性应激和氧化应激作为抑郁症和阿尔茨海默病发病机制的共同因素；抗氧化剂在预防和治疗中的作用

越来越多的科学研究表明，阿尔茨海默病 (AD) 中的抑郁症和痴呆症之间存在联系。慢性应激有助于在参与抑郁症和 AD 发展的大脑部分形成氧化应激。科学文献报道了抗氧化剂的重要作用，抗氧化剂在治疗这些疾病方面非常有效。在这篇综述中，我们总结了慢性压力、氧化压力以及它们在大脑中引起的大脑变化之间的关系。在所有显示抗氧化特性的化合物中，维生素 E、辅酶 Q10 (CoQ10)、褪黑激素、多酚、姜黄素和硒在 AD 治疗中观察到最有希望的结果。在治疗抑郁症的情况下，姜黄素、锌、硒、维生素 E、