Qianbai biyan tablet (QT) is a compound prescription of traditional Chinese medicine which is used to treat nasal congestion, rhinitis, and nasosinusitis, with Senecio scandens as its main plant material. Several pyrrolizidine alkaloids (PAs) were reported in Senecio scandens and others of Senecio species. Although Senecio scandens is assigned as the legal plant material of QT, whether replaced use of it by other Senecio plants can bring toxicity is unknown because of the lack of quantitative data about toxic PAs between different Senecio species. In the present study, adonifoline, senkirkine, and another PA presumed as emiline have been identified in QT; however, there was no senecionine detected in all tablets. PA contents in QTs varied in different companies and different batches. Adonifoline existed only in Senecio scandens, and senecionine was detected in all eight Senecio plants investigated in the present study. Data showed that replaced use of Senecio scandens with a low level of senecionine by other Senecio plants such as Senecio vulgaris containing a high level of senecionine is advertised to be forbidden. Data of the present study may be used as a reference to make new drug quality regularity and recommendation guideline for the safety of QT.

中文翻译：

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中药复方千白鼻炎片中主要毒性吡咯里西啶生物碱的鉴定与同时测定

千白鼻咽片（QT）是一种以千里光为主要植物原料，用于治疗鼻塞、鼻炎、鼻窦炎的中药复方。在千里光和其他千里光物种中报道了几种吡咯里西啶生物碱 (PA) 。虽然千里光被指定为 QT 的合法植物材料，但由于缺乏不同千里光之间有毒 PA 的定量数据，被其他千里光植物替代使用是否会带来毒性尚不得而知。物种。在本研究中，已在 QT 中鉴定出阿多尼叶林、senkirkine 和另一种被假定为 emiline 的 PA；然而，在所有片剂中均未检测到 senecionine。不同公司、不同批次的QT中PA含量不同。Adonifoline 仅存在于千里光中，在本研究中调查的所有八种千里光植物中都检测到千里光碱。数据显示，其他千里光植物（如千里光）用低含量的千里光替代了千里光的使用含有高水平 senecionine 的广告被禁止。本研究数据可作为新药质量规律和QT安全性推荐指南的参考。