Background. The purpose of this meta-analysis was to assess the clinical efficacy of etoricoxib in comparison with traditional NSAIDs for postoperative pain after third molar surgery. Methods. The quality of studies found in PubMed and Google Scholar was evaluated with Cochrane Collaboration’s risk of bias tool. Data on total consumption of rescue analgesics, number of patients using rescue analgesics, global assessment of study treatments, and adverse effects were extracted exclusively from high-quality clinical trials. Each meta-analysis was performed with the Review Manager Software 5.3 for Windows. Results. The qualitative analysis showed that etoricoxib has better analgesic activity when compared with ibuprofen (2 clinical trials) and diclofenac (1 clinical trial). A similar analgesic efficacy between etoricoxib and nonselective Cox-2 NSAIDs was informed in 3/8 studies (2 compared to ibuprofen and 1 to naproxen sodium). Moreover, the number of patients requiring rescue analgesics in the postoperative period showed a statistical difference in favor of etoricoxib when compared to NSAIDs. Conclusion. Etoricoxib significantly reduces the number of patients needing rescue analgesics compared to NSAIDs after third molar surgery.

中文翻译：

---

第三磨牙手术后依托考昔的镇痛效果：荟萃分析

背景。这项荟萃分析的目的是评估依托考昔与传统非甾体抗炎药相比对第三磨牙术后疼痛的临床疗效。方法。在 PubMed 和 Google Scholar 中发现的研究质量使用 Cochrane Collaboration 的偏倚风险工具进行评估。有关急救镇痛药的总消耗量、使用急救镇痛药的患者人数、研究治疗的全球评估和不良反应的数据完全来自高质量的临床试验。每项荟萃分析均使用适用于 Windows 的 Review Manager 软件 5.3 进行。结果. 定性分析表明，与布洛芬（2 项临床试验）和双氯芬酸（1 项临床试验）相比，依托考昔具有更好的镇痛活性。3/8 的研究表明，依托考昔和非选择性 Cox-2 NSAID 的镇痛效果相似（2 项与布洛芬相比，1 项与萘普生钠相比）。此外，与非甾体抗炎药相比，术后需要急救镇痛药的患者数量显示出有利于依托考昔的统计学差异。结论。与第三磨牙手术后的非甾体抗炎药相比，依托考昔显着减少了需要抢救性镇痛药的患者数量。