Three versatile half-sandwich ruthenium(II) p-cymene complexes bearing substituted triazole ligands exhibit promising cancer cell growth inhibition activity towards A549 lung adenocarcinoma and MDA-MB-231 breast adenocarcinoma cells. In this context, the triazole based phthalimide protected new ligand (2-(3, 5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl) isoindoline-1,3-dione) (L¹) was prepared. Three ruthenium(II) p-cymene complexes [Ru(η⁶-p-cymene)(L¹)Cl]Cl: [1]Cl, L¹: (2-(3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione), [Ru(η⁶-p-cymene)(L²)Cl]Cl: [2]Cl and [Ru(η⁶-p-cymene)(L²)Cl](PF₆): [2](PF₆), L² (2,2′-(4-(1H-pyrrol-1-yl)-4H-1,2,4-triazole-3,5-diyl) dipyridine) have been successfully synthesized and characterized by different spectral and analytical tools. Pyrrole protected substituted ruthenium complexes [2]Cl and [2](PF₆) have been successfully identified structurally by single-crystal X-ray diffraction studies and confirmed the successful anion exchange. The redox properties of the ligands and the targeted metal complexes have been carefully examined. Cellular staining, live-cell imaging and MTT assay have been performed for all the complexes. We have demonstrated that our synthesized ruthenium(II) p-cymene complexes are capable of inducing significant cytotoxicity in A549 lung cancer cell lines, with an IC₅₀ values of 6.56 ± 0.31 µM, 4.74 ± 0.2 µM and 13.67 ± 0.64 µM and in MDA-MB-231 breast cancer cell lines with an IC₅₀ values of 1.13 ± 0.046 µM, 0.36 ± 0.016 µM and 11.32 ± 0.49 µM for [1]Cl, [2]Cl and [2](PF₆) respectively.

三种带有取代三唑配体的多功能半夹心钌 (II) p-伞花烃复合物对 A549 肺腺癌和 MDA-MB-231 乳腺癌细胞具有良好的癌细胞生长抑制活性。在这种情况下，基于三唑的邻苯二甲酰亚胺保护了新的配体 (2-(3, 5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione) ( L ¹ )被制备。三种钌 (II)对伞花烃配合物 [Ru(η ⁶ - p -伞花烃)( L ¹ )Cl]Cl: [ 1 ]Cl, L ¹ : (2-(3,5-di(pyridin-2-yl )-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione), [Ru(η ⁶ - p-伞花烃)( L ² )Cl]Cl: [ 2 ]Cl 和 [Ru(η ⁶ - p -伞花烃)( L ² )Cl](PF ₆ ): [ 2 ](PF ₆ ), L ² (2, 2'-(4-(1H-pyrrol-1-yl)-4H-1,2,4-triazole-3,5-diyl) dipyridine) 已成功合成并通过不同的光谱和分析工具进行表征。吡咯保护的取代钌配合物 [ 2 ]Cl 和 [ 2 ](PF ₆) 已通过单晶 X 射线衍射研究在结构上成功鉴定，并证实了成功的阴离子交换。配体和目标金属配合物的氧化还原特性已经过仔细检查。已对所有复合物进行细胞染色、活细胞成像和 MTT 测定。我们已经证明我们合成的钌 (II)对伞花烃复合物能够在 A549 肺癌细胞系中诱导显着的细胞毒性，IC ₅₀值为 6.56 ± 0.31 µM、4.74 ± 0.2 µM 和 13.67 ± 0.64 µM，并且在 MDA 中-MB-231 乳腺癌细胞系的 IC ₅₀值为 1.13 ± 0.046 µM、0.36 ± 0.016 µM 和 11.32 ± 0.49 µM，对于 [ 1 ]Cl、[ 2 ]Cl 和 [ 2 ]](PF ₆ )。