Excessive UV irradiation induces photoaging and overproduction of melanin, which darkens the skin and affects appearance. To efficiently enhance transdermal delivery and anti-pigmentation, a novel ROS-responsive transdermal nanocarrier for the whitening agent Glabridin by integrating the cell-penetrating peptide polyarginine R8 and borate ester bond into hollow mesoporous silica nanoparticles (HMSNs) has been designed, in which beta-cyclodextrin (β-CD) was grafted onto the surfaces of HMSNs via boronic ester bond to avoid premature release of Glabridin, and R8 conjugated adamantane (Ada) was anchored on HMSN-β-CD via host-gust interaction to enhance the drug delivery efficiency. The ROS-responsive HMSN-β-CD/Ada-R8 nanocarrier was characterized by TEM, FTIR, TGA, Zeta potential, N₂ adsorption, stability, and other parameters. The nanocarrier rapidly penetrated through the epidermis into the keratinocytes and melanocytes and released Glabridin in a controlled ROS-responsive manner. Glabridin released from nanocarriers reversed UV-induced oxidative damage and phototoxicity and reduced hyperpigmentation. Taken together, our study provides a guidance for the design and fabrication of functional transdermal drug nanocarriers for cosmetic applications.

过度的紫外线照射会导致光老化和黑色素过度生成，从而使皮肤变黑并影响外观。为了有效地增强透皮递送和抗色素沉着，通过将细胞穿透肽聚精氨酸 R8 和硼酸酯键整合到空心介孔二氧化硅纳米粒子 (HMSNs) 中，设计了一种用于美白剂光甘草定的新型 ROS 响应性透皮纳米载体，其中β -环糊精（β-CD）通过硼酸酯键接枝到HMSNs表面以避免光甘草定过早释放，R8共轭金刚烷（Ada）通过宿主-阵风相互作用锚定在HMSN-β-CD上以增强药物递送效率。ROS响应性HMSN-β-CD/Ada-R8纳米载体通过TEM、FTIR、TGA、Zeta电位、N ₂表征吸附、稳定性等参数。纳米载体迅速穿透表皮进入角质形成细胞和黑色素细胞，并以受控的 ROS 响应方式释放光甘草定。从纳米载体释放的光甘草定可逆转紫外线引起的氧化损伤和光毒性，并减少色素沉着过度。总之，我们的研究为用于化妆品应用的功能性透皮药物纳米载体的设计和制造提供了指导。