P53 overexpression has been shown to involve in mitochondria-mediated dapaminergic neuron cell death in Parkinson's disease. However, the exactly molecular mechanisms responsible for the p53-dependent intrinsic cell death in neurodegenerative conditions remain unclearly. Annexin A2 is a multifunctional protein that negatively regulates p53 expression. The purpose of this study was to explore the mechanism of p53 dependent dopaminergic cell death and implication of Annexin A2 in cellular apoptosis in 1-methyl-4-phenylpyridinium (MPP+)-induced PC12 cells.

中文翻译：

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膜联蛋白 A2 降解通过调节神经退行性疾病中的 p53 促进多巴胺能细胞凋亡。

P53 过表达已被证明与帕金森病中线粒体介导的达巴胺能神经元细胞死亡有关。然而，神经退行性疾病中p53依赖性内在细胞死亡的确切分子机制仍不清楚。膜联蛋白 A2 是一种负向调节 p53 表达的多功能蛋白。本研究的目的是探讨 p53 依赖性多巴胺能细胞死亡的机制以及膜联蛋白 A2 在 1-甲基-4-苯基吡啶 (MPP+) 诱导的 PC12 细胞细胞凋亡中的意义。