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Adult gonococcal conjunctivitis: Prevalence, clinical features and complications
Journal of Medical Microbiology ( IF 3 ) Pub Date : 2021-09-08 , DOI: 10.1099/jmm.0.001416
Genoveva Cuesta Chasco 1 , Xavier Carreras-Castañer 2 , Yuliya Zboromyrska 1 , Cristina Pitart 1 , Francisco Palma-Carvajal 2 , Jordi Bosch 1 , Juan Pablo Figueroa-Vercellino 2
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Introduction. Gonorrhoea is a sexually transmitted disease whose incidence has increased in recent years and adult gonococcal conjunctivitis (AGC) is a relatively uncommon complication. Hypothesis/Gap Statement. AGC is associated with increased incidence of genital gonorrhoea and must be treated correctly to avoid serious corneal complications. Aims. To report the prevalence, clinical features, and complications of AGC in a tertiary ophthalmology centre in Barcelona, Spain. Present epidemiological data, clinical features, ocular complications, and antibiotic susceptibility. Design: Single-centre, descriptive, retrospective case series. Methodology. Systematic case-defined search in medical records and further retrospective chart review study of microbiologically confirmed AGC attending outpatient clinic and/or emergency room from 2012 to 2020. We analysed the clinical presentation, treatments, antibiotic susceptibility, complications and ocular sequelae. Results. Thirteen patients were diagnosed of AGC. Eleven patients had unilateral presentation. Two patients had bilateral presentation. In ten cases there was abundant mucopurulent discharge, three cases presented periocular pain and periocular inflammation requiring a CT scan to rule out post-septal cellulitis. The diagnosis was confirmed by culture. In total, 100 % of strains were susceptible to ceftriaxone, 58 % were ciprofloxacin resistant and no beta-lactamase production was detected. Three patients required hospital admission. One patient developed a complication presenting with ptosis caused by superior symblepharon. Conclusion. AGC is a rare disease which is difficult to diagnose as it requires a high index of suspicion to prevent corneal perforation but in an important number of cases it may mimic orbital cellulitis. It is crucial that treatment starts as soon as possible to avoid serious corneal damage. Patients should promptly receive complete and correct treatment when admitted to the emergency room since an elevated number of patients do not attend their medical follow-up visit. Azithromycin or aminoglycoside eye drops are probably the best option to complete the treatment, due to high quinolone resistance.

中文翻译:

成人淋球菌性结膜炎:患病率、临床特征和并发症

介绍。淋病是一种性传播疾病,近年来发病率有所增加,成人淋球菌性结膜炎 (AGC) 是一种相对少见的并发症。假设/差距陈述。AGC 与生殖器淋病的发病率增加有关,必须正确治疗以避免严重的角膜并发症。目标。报告西班牙巴塞罗那三级眼科中心 AGC 的患病率、临床特征和并发症。提供流行病学数据、临床特征、眼部并发症和抗生素敏感性。设计:单中心、描述性、回顾性病例系列。方法。对 2012 年至 2020 年在门诊和/或急诊室就诊的微生物确诊 AGC 进行系统病例定义搜索和进一步回顾性图表审查研究。我们分析了临床表现治疗、抗生素敏感性、并发症和眼部后遗症。结果。13 名患者被诊断为 AGC。11 名患者有单侧表现。两名患者有双侧表现。10 例有大量粘液脓性分泌物,3 例出现眼周疼痛和眼周炎症,需要进行 CT 扫描以排除间隔后蜂窝织炎。通过培养证实了诊断。总的来说,100% 的菌株对头孢曲松敏感,58% 的菌株对环丙沙星有抗性,并且没有检测到 β-内酰胺酶的产生。三名患者需要住院。一名患者出现了上睑下垂引起的并发症。结论。AGC 是一种难以诊断的罕见疾病,因为它需要高度怀疑以防止角膜穿孔,但在很多情况下,它可能与眼眶蜂窝织炎相似。尽快开始治疗以避免严重的角膜损伤至关重要。患者在进入急诊室时应立即接受完整和正确的治疗,因为没有参加医疗随访的患者人数增加。由于喹诺酮类药物耐药性高,阿奇霉素或氨基糖苷类滴眼液可能是完成治疗的最佳选择。
更新日期:2021-09-09
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