MiR-375 is a conserved noncoding RNA that is known to be involved in tumor cell proliferation, migration, and drug resistance. Previous studies have shown that miR-375 affects the epithelial-mesenchymal transition (EMT) of human tumor cells via some key transcription factors, such as Yes-associated protein 1 (YAP1), Specificity protein 1 (SP1) -and signaling pathways (Wnt signaling pathway, nuclear factor kappa B (NF-kB) pathway and transforming growth factor β (TGF-β) signaling pathway) and is vital for the development of cancer. Additionally, recent studies have identified miRNA delivery system carriers for improved in vivo transportation of miR-375 to specific sites. Here, we discussed the role of miR-375 in different types of cancers, as well as molecular mechanisms, and analyzed the potential of miR-375 as a molecular biomarker and therapeutic target to improve the efficiency of clinical diagnosis of cancer.

中文翻译：

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MicroRNA-375：潜在的癌症抑制剂和治疗药物。

MiR-375 是一种保守的非编码 RNA，已知与肿瘤细胞增殖、迁移和耐药性有关。先前的研究表明，miR-375 通过一些关键的转录因子影响人类肿瘤细胞的上皮间质转化（EMT），例如 Yes 相关蛋白 1（YAP1）、特异性蛋白 1（SP1）和信号通路（Wnt信号通路、核因子 kappa B (NF-kB) 通路和转化生长因子 β (TGF-β) 信号通路)，对癌症的发展至关重要。此外，最近的研究已经确定了 miRNA 递送系统载体，用于改善 miR-375 到特定位点的体内运输。在这里，我们讨论了 miR-375 在不同类型癌症中的作用，以及分子机制，