In recent years, bioactive peptide drugs have attracted growing attention due to the increasing difficulty in developing new drugs with novel chemical structures. In addition, many diseases are linked to excessive oxidation in the human body. Therefore, the role of peptides with antioxidant activity in counteracting diseases related to oxidative stress is worth exploring. Amphibians are a major repository for bioactive peptides that protect the skin from biotic and abiotic stresses, such as microbial infection and radiation injury. We characterized the first amphibian- derived gene-encoded antioxidant peptides in 2008. Since then, a variety of antioxidant peptides have been detected in different amphibian species. In this work, the physicochemical properties of antioxidant peptides identified from amphibians are reviewed for the first time, particularly acquisition methods, amino acid characteristics, antioxidant mechanisms, and application prospects. This review should provide a reference for advancing the identification, structural analysis, and potential therapeutic value of natural antioxidant peptides.

近年来，由于开发具有新化学结构的新药的难度越来越大，生物活性肽药物越来越受到关注。此外，许多疾病与人体内的过度氧化有关。因此，具有抗氧化活性的肽在对抗氧化应激相关疾病中的作用值得探索。两栖动物是生物活性肽的主要储存库，可保护皮肤免受生物和非生物压力，例如微生物感染和辐射损伤。我们在 2008 年对第一个两栖动物衍生的基因编码的抗氧化肽进行了表征。从那时起，在不同的两栖动物物种中检测到了多种抗氧化肽。本工作首次综述了从两栖动物中鉴定的抗氧化肽的理化性质，特别是获取方法、氨基酸特性、抗氧化机制和应用前景。本综述应为推进天然抗氧化肽的鉴定、结构分析和潜在治疗价值提供参考。