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A new small-molecule compound, Q308, silences latent HIV-1 provirus by suppressing Tat- and FACT-mediated transcription
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-09-07 , DOI: 10.1128/aac.00470-21
Chen-Liang Zhou 1 , Yi-Fan Huang 1 , Yi-Bin Li 1 , Tai-Zhen Liang 1 , Teng-Yi Zheng 1 , Pei Chen 1 , Zi-Yao Wu 1 , Fang-Yuan Lai 1, 2 , Shu-Wen Liu 1 , Bao-Min Xi 1 , Lin Li 1
Affiliation  

Eliminating the latent HIV reservoir remains a difficult problem for creating an HIV functional cure or achieving remission. The “block-and-lock” strategy aims to steadily suppress transcription of the viral reservoir and lock the HIV promoter in deep ...

中文翻译:

一种新的小分子化合物 Q308 通过抑制 Tat 和 FACT 介导的转录来沉默潜伏的 HIV-1 前病毒

消除潜在的 HIV 宿主对于创造 HIV 功能性治愈或实现缓解仍然是一个难题。“阻断和锁定”策略旨在稳定地抑制病毒库的转录并将 HIV 启动子锁定在深...
更新日期:2021-09-12
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