Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis,Journal of Child Psychology and Psychiatry

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Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis
Journal of Child Psychology and Psychiatry ( IF 7.6 ) Pub Date : 2021-09-07 , DOI: 10.1111/jcpp.13518
Laurel A Fish ₁ , Pär Nyström ₂ , Teodora Gliga ₃ , Anna Gui ₄ , Jannath Begum Ali ₄ , Luke Mason ₄ , Shruti Garg ₅ , Jonathan Green ₅ , Mark H Johnson _{4,

6} , Tony Charman ₇ , Rebecca Harrison ₄ , Emma Meaburn ₄ , Terje Falck-Ytter _{8,

9,

10} , Emily J H Jones ₄ ,

Affiliation

Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Uppsala Child & Babylab, Department of Psychology, Uppsala University, Uppsala, Sweden.
School of Psychology, University of East Anglia, Norwich, UK.
Department of Psychological Sciences, Birkbeck College, University of London, London, UK.
Neuroscience & Experimental Psychology, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Department of Psychology, Cambridge University, Cambridge, UK.
Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Development and Neurodiversity Lab (DIVE), Department of Psychology, Uppsala University, Uppsala, Sweden.
Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Swedish Collegium for Advanced Study (SCAS), Uppsala, Sweden.

Although autism spectrum disorder (ASD) is heritable, the mechanisms through which genes contribute to symptom emergence remain unclear. Investigating candidate intermediate phenotypes such as the pupillary light reflex (PLR) prospectively from early in development could bridge genotype and behavioural phenotype.

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