The difficulties in performing experimental studies related to diseases of the human brain have fostered a range of disease models from highly expensive and complex animal models to simple, robust, unicellular yeast models. Yeast models have been used in numerous studies to understand Alzheimer’s disease (AD) pathogenesis and to search for drugs targeting AD. Thanks to the conservation of fundamental eukaryotic processes including ageing and the availability of appropriate technological platforms, budding yeast are a simple model eukaryote to assist with understanding human cell biology, offering a platform to study human diseases. This article aims to provide insights from yeast models on the contributions of amyloid beta, a causative agent in AD, and recent research findings on AD chemoprevention.

进行与人类大脑疾病相关的实验研究的困难催生了一系列疾病模型，从非常昂贵和复杂的动物模型到简单、强大的单细胞酵母模型。酵母模型已被用于许多研究，以了解阿尔茨海默病 (AD) 的发病机制并寻找针对 AD 的药物。由于包括衰老在内的基本真核过程的保护和适当技术平台的可用性，芽殖酵母是一种简单的真核生物模型，可帮助理解人类细胞生物学，提供研究人类疾病的平台。本文旨在从酵母模型中提供关于淀粉样蛋白 β（AD 的病原体）的贡献的见解，以及有关 AD 化学预防的最新研究结果。