SARS-CoV-2 harbors many known unknown regions in the form of hypothetical open reading frames (ORFs). While the mechanisms underlying the disease pathogenesis are not clearly understood, molecules such as long noncoding RNAs (lncRNAs) play a key regulatory role in the viral pathogenesis from endocytosis. We asked whether or not the lncRNAs in the host are associated with the viral proteins and argue that lncRNA-mRNA molecules related to viral infection may regulate SARS-CoV-2 pathogenesis. Towards the end of the perspective, we provide challenges and insights into investigating these transgression pathways.

中文翻译：

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SARS-CoV-2 超越 LncRNA 揭示已知的未知数


SARS-CoV-2 以假设的开放阅读框 (ORF) 的形式包含许多已知的未知区域。虽然疾病发病机制的机制尚不清楚，但长非编码 RNA (lncRNA) 等分子在内吞作用的病毒发病机制中发挥着关键的调节作用。我们询问宿主体内的 lncRNA 是否与病毒蛋白相关，并认为与病毒感染相关的 lncRNA-mRNA 分子可能调节 SARS-CoV-2 的发病机制。在视角的最后，我们提供了调查这些越界途径的挑战和见解。