Naive CD8⁺ T cells, upon encountering their cognate Ag in vivo, clonally expand and differentiate into distinct cell fates, regulated by transcription factors and epigenetic modulators. Several models have been proposed to explain the differentiation of CTLs, although none fully recapitulate the experimental evidence. In this review article, we will summarize the latest research on the epigenetic regulation of CTL differentiation as well as provide a combined model that contemplates them.

中文翻译：

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效应和记忆 CD8+ T 细胞分化表观遗传调控的更新模型

幼稚 CD8 ⁺ T 细胞在体内遇到它们的同源 Ag 后，会克隆扩增并分化为不同的细胞命运，受转录因子和表观遗传调节剂的调节。已经提出了几种模型来解释 CTL 的分化，但没有一个模型能够完全概括实验证据。在这篇综述文章中，我们将总结关于 CTL 分化的表观遗传调控的最新研究，并提供一个考虑它们的组合模型。