Coronary heart disease (CHD) is the leading cause of human death worldwide. Genetic factors play an important role in the occurrence of CHD. Our study is designed to investigate the influence of CYP7B1 polymorphisms on CHD risk. In this case–control study, 508 CHD patients and 510 healthy individuals were recruited to determine the correlation between CYP7B1 polymorphisms (rs7836768, rs6472155, and rs2980003) and CHD risk. The associations were evaluated by computing odds ratios (OR) and 95% confidence intervals (CI) with logistic regression analysis. The association between SNP-SNP interaction and CHD susceptibility was carried out by multifactor dimensionality reduction analyses. Our study found that rs6472155 is significantly associated with an increased risk of CHD in age > 60 years (OR 2.20, 95% CI = 1.07–4.49, p = 0.031), women (OR 3.17, 95% CI = 1.19–8.44, p = 0.021), and non-smokers (3.43, 95% CI = 1.16–10.09, p = 0.025). Rs2980003 polymorphism has a lower risk of CHD in drinkers (OR 0.47, 95% CI = 0.24–0.91, p = 0.025). Further analyses based on false-positive report probability validated these significant results. Besides, it was found that rs6472155 polymorphism was associated with uric acid level (p = 0.034). Our study indicated that CYP7B1 polymorphisms are related to the risk of CHD, which provides a new perspective for prevent of CHD.

中文翻译：

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CYP7B1多态性对海南汉族人群冠心病风险的影响


冠心病（CHD）是全世界人类死亡的主要原因。遗传因素在CHD的发生中起着重要作用。我们的研究旨在调查 CYP7B1 多态性对 CHD 风险的影响。在这项病例对照研究中，招募了 508 名 CHD 患者和 510 名健康个体，以确定 CYP7B1 多态性（rs7836768、rs6472155 和 rs2980003）与 CHD 风险之间的相关性。通过逻辑回归分析计算比值比 (OR) 和 95% 置信区间 (CI) 来评估关联性。通过多因素降维分析，研究了 SNP-SNP 相互作用与 CHD 易感性之间的关联。我们的研究发现，rs6472155 与年龄 > 60 岁（OR 2.20，95% CI = 1.07–4.49，p = 0.031）、女性（OR 3.17，95% CI = 1.19–8.44， p = 0.021）和非吸烟者（3.43，95% CI = 1.16–10.09，p = 0.025）。 Rs2980003 多态性使饮酒者患冠心病的风险较低（OR 0.47，95% CI = 0.24–0.91，p = 0.025）。基于假阳性报告概率的进一步分析验证了这些重要结果。此外，还发现rs6472155多态性与尿酸水平相关（p = 0.034）。我们的研究表明CYP7B1多态性与冠心病的发病风险相关，这为冠心病的预防提供了新的视角。