Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizumab infusion in a patient with JIA. A 14-year-old female patient with polyarticular JIA developed interstitial lung disease after intravenous and subcutaneous administration of tocilizumab. Her condition improved with glucocorticoid therapy. Our results suggest that increased interleukin-6 levels in the blood following tocilizumab treatment may be linked to development of interstitial lung disease.

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多关节型幼年特发性关节炎患者输注托珠单抗后不久发生间质性肺病：病例报告

托珠单抗已被证明可有效治疗幼年特发性关节炎 (JIA)。据我们所知，这是 JIA 患者输注托珠单抗后不久发生间质性肺病的首例报道。一名患有多关节型 JIA 的 14 岁女性患者在静脉和皮下注射托珠单抗后出现间质性肺病。她的病情在糖皮质激素治疗后有所改善。我们的结果表明，托珠单抗治疗后血液中白细胞介素 6 水平升高可能与间质性肺病的发生有关。